Ligustilide
Cat. No. :YN280129
CAS No. :4431-01-0
86-020-82000279
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order@ubiochem.com| Product Name: | Ligustilide |
| CAS NO.: | 4431-01-0 |
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| Molecular Weight: | 190.24 |
| Molecular Formula: | C₁₂H₁₄O₂ |
| SMILES: | O=C1O/C(C2=C1C=CCC2)=CCCC |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | Ligustilide may have the neuroprotective potential of Ligustilide in cerebral ischemic damage via antioxidant and anti-apoptotic properties. Ligustilide and senkyunolide A have vasorelaxation activities in contractions to various contractile agents in rat isolated aorta. Ligustilide possesses antinociceptive and anti-inflammatory activities, also has an active dilatory effect on myometrium and an effective role in reducing the neurogenic and inflammatory pain, thus it has the potential to be developed into an effective drug for the treatment of various pain syndromes including primary dysmenorrhoea. Ligustilide exhibits anti-inflammatory activities by blocking the activation of MAPKs/IKK and the downstream transcription factors AP-1 and NF-κB, which may result from ligustilide's down-regulation of iROS production. Ligustilide has therapeutic effect against (AD)-like neuropathologies, it upregulates Klotho expression in the cerebral choroid plexus and serum, decreases and Forkhead box class O1 and inhibits the -like growth factor 1 pathway and induces Forkhead box class O1 activation in 293T cells along with Klotho upregulation. |
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