NKH477
Cat. No. :YN320245
CAS No. :138605-00-2
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order@ubiochem.com| Product Name: | NKH477 |
| CAS NO.: | 138605-00-2 |
| Chemical Name: | |
| Synonyms: | |
| Molecular Weight: | 546.09 |
| Molecular Formula: | C₂₇H₄₄ClNO₈ |
| SMILES: | O[C@@]12[C@@]3([C@@](C(C)(CC[C@@H]3O)C)([H])[C@H](OC(CCN(C)C)=O)[C@H](OC(C)=O)[C@]1(O[C@](C=C)(C)CC2=O)C)C.Cl |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | NKH477 (Colforsin dapropate hydrochloride) is a novel water-soluble forskolin derivative that improves cardiac failure mainly through its beneficial effects on diastolic cardiac function. NKH477 directly activates the catalytic unit ofadenylate cyclase and increases intracellular cAMP. NKH477 exerts an antiproliferative effect in vivo with an altered cytokine profile to inhibit the acute rejection of rat orthotopic lung allografts. |
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