SCH79797 dihydrochloride
Cat. No. :YN320938
CAS No. :1216720-69-2
86-020-82000279
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order@ubiochem.com| Product Name: | SCH79797 dihydrochloride |
| CAS NO.: | 1216720-69-2 |
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| Molecular Weight: | 444.40 |
| Molecular Formula: | C₂₃H₂₇Cl₂N₅ |
| SMILES: | Cl[H].Cl[H].NC1=NC(NC2CC2)=NC3=CC=C(N(CC4=CC=C(C(C)C)C=C4)C=C5)C5=C31 |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | SCH79797 dihydrochloride is a highly potent, selective nonpeptideprotease activated receptor 1 (PAR1)antagonist. SCH79797 dihydrochloride inhibits binding of a high-affinity thrombin receptor-activating peptide toPAR1with an IC50 of 70nM and a Ki of 35nM. SCH79797 dihydrochloride inhibits thrombin-induced platelet aggregation with an IC50 of 3μM. SCH79797 dihydrochloride has antiproliferative and pro-apoptoticeffects, and limits myocardial ischemia/reperfusion injury in rat hearts. SCH79797 dihydrochloride also potently preventsPAR1activation in vascular smooth muscle cells, endothelial cells, and astrocytes. |
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