Ruscogenin
Cat. No. :YN330558
CAS No. :472-11-7
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price
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5mg
$ 110.00
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order@ubiochem.com| Product Name: | Ruscogenin |
| CAS NO.: | 472-11-7 |
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| Molecular Weight: | 430.62 |
| Molecular Formula: | C₂₇H₄₂O₄ |
| SMILES: | C[C@@]12[C@]([C@@H]3C)([H])[C@](O[C@]34CC[C@@H](C)CO4)([H])C[C@@]1([H])[C@@](CC=C(C[C@@H](O)C5)[C@@]6([C@@H]5O)C)([H])[C@]6([H])CC2 |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | Ruscogenin has been found to exert significant anti-inflammatory and anti-thrombotic activities; the possible mechanism of the anti-inflammatory activity is role of intercellular adhesion molecule-1 and nuclear factor-kappaB. Ruscogenin significantly attenuates LPS-induced acute lung injury (ALI )via inhibiting expressions of TF and iNOS and NF-κB p65 activation, indicates that it as a potential therapeutic agent for ALI or sepsis. Ruscogenin can protect the brain against ischemic damage caused by middle cerebral artery occlusion (MCAO), and this effect may be through downregulation of NF-κB-mediated inflammatory responses. Ruscogenin inhibits activation of neutrophil through cPLA 2 , PAK, Akt, MAPKs, cAMP, and PKA signaling pathways. Ruscogenin may attenuate high-fat diet (HFD)-induced steatohepatitis through downregulation of NF- κB-mediated inflammatory responses, reducing hepatic lipogenic gene expression, and upregulating proteins in β-oxidation pathway. |
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