AZD1283
Cat. No. :YN321035
CAS No. :919351-41-0
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order@ubiochem.com| Product Name: | AZD1283 |
| CAS NO.: | 919351-41-0 |
| Chemical Name: | |
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| Molecular Weight: | 470.54 |
| Molecular Formula: | C₂₃H₂₆N₄O₅S |
| SMILES: | CC1=C(C(OCC)=O)C=C(C#N)C(N2CCC(C(NS(=O)(CC3=CC=CC=C3)=O)=O)CC2)=N1 |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | AZD1283 is a potent antagonist of the P2Y12 receptor with EC50 of 3.0 ug/kg/min, TI >10; with binding IC50 of 11nM. AZD1283 dose-dependently induced increases in blood flow and inhibition of ADP-induced platelet aggregation with antithrombotic ED50 values of 3.0 and 10 μg/kg/min, respectively. The doses that induced a larger than 3-fold increase in bleeding time were 33 and 100 μg/kg/min for 3 and 13, respectively. Thus, the therapeutic index (TI) was ≥10 for both compounds. On the basis of these data, compound 3 was progressed into human clinical trials as c and idate drug AZD1283. |
| IC50&Target: | |
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