ICA-121431
Cat. No. :YN360592
CAS No. :313254-51-2
86-020-82000279
sales@ubiochem.com
order@ubiochem.com| Product Name: | ICA-121431 |
| CAS NO.: | 313254-51-2 |
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| Molecular Weight: | 449.55 |
| Molecular Formula: | C₂₃H₁₉N₃O₃S₂ |
| SMILES: | O=C(NC1=CC=C(S(NC2=NC=CS2)(=O)=O)C=C1)C(C3=CC=CC=C3)C4=CC=CC=C4 |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | ICA-121431 is a nanomolar potent and broad-spectrumvoltage-gated sodium channel (Nav)blocker, shows equipotent selectivity for human Nav1.1 and Nav1.3 subtypes with IC50 values of 13nM and 23nM, respectively. ICA-121431 shows less potent inhibition of Nav1.2 (IC50=240nM) and 1,000 fold selectivity against Nav1.4, Nav1.6, and the TTX-resistant human Nav1.5 and Nav1.8 channels (IC50s >10 µM). |
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