YN320085 Zibotentan 186497-07-4

Zibotentan (ZD4054) is a specific Endothelin (ET)A antagonist with IC50 of 21 nM, exhibiting no activity at ETB. Phase 3.

YN321212 ZD-1611 186497-38-1

ZD-1611 is a potent, orally active, selectiveETA receptorantagonist, used for the research of ischemic stroke.

YN320532 A-192621 195529-54-5

A-192621 is a potent, nonpeptide, orally active and selectiveendothelin B (ETB) receptorantagonist with an IC50 of 4.5nM and a Ki of 8.8nM. The selectivity of A-192621 is 636-fold higher than ETA(IC50 of 4280nM and K...

YN320975 Atrasentan hydrochloride 195733-43-8

Atrasentan hydrochloride (ABT-627 hydrochloride) is a selectiveendothelin A receptorantagonist with an IC50 of 0.0551nM for ETA.

YN320427 Sitaxsentan sodium 210421-74-2

Sitaxsentan sodium (IPI 1040 sodium; TBC11251 sodium) is an orally active, highly selective antagonist ofendothelin A receptors.

YN320750 ABT-546 212481-66-8

ABT-546 (A-216546) is a potent, highly selective and activeendothelin ETAreceptorantagonist with a Ki of 0.46nM for [125I]endothelin-1 binding to clonedhuman endothelin ETA. ABT-546 is ＞25,000-fold more selective for theE...

YN320947 Avosentan 290815-26-8

Avosentan(Ro 67-0565; SPP-301) is a potent, selective endothelin receptor(ETA receptor) antagonist.

YN320312 Nebentan potassium 342005-82-7

Nebentan potassium (YM598) is a potent, selective and orally active non-peptideendothelin ETAreceptorantagonist through the modification of Bosentan (HY-A0013). Nebentan potassium inhibits [125I] endothelin-1 binding to cloned...

YN320311 Nebentan 403604-85-3

Nebentan (YM598 free base) is a potent, selective and orally active non-peptideendothelin ETAreceptorantagonist through the modification of Bosentan (HY-A0013). Nebentan inhibits [125I] endothelin-1 binding to cloned human end...

YN320831 Macitentan 441798-33-0

Macitentan is an orally active, non-peptide, dual ETA/ETB (endothelin) receptor antagonist with IC50 of 0.5 nM/391 nM.

YN320832 Macitentan (n-butyl analogue) 556797-16-1

Macitentan n-butyl analogue is a n-butyl analogue of Macitentan. Macitentan is an orally active, non-peptide dual endothelinETA and ETB receptorantagonist for the potential treatment of idiopathic pulmonary fibrosis (IPF) and ...

YN321048 Aprocitentan 1103522-45-7

Aprocitentan (ACT-132577) is the major and pharmacologically active metabolite of Macitentan. Aprocitentan is dualETA/ETBantagonist with IC50s of 3.4nM and 987nM, and pA2valus of 6.7 and 5.5, respectively.

YN321878 Atrial Natriuretic Peptide ... 1366000-58-9

Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate is a 28-amino acid hormone, that is normally produced and secreted by the human heart in response to cardiac injury and mechanical stretch. ANP (1-28) inhibitsend...