Otamixaban
Cat. No. :YN372660
CAS No. :193153-04-7
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order@ubiochem.com| Product Name: | Otamixaban |
| CAS NO.: | 193153-04-7 |
| Chemical Name: | |
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| Molecular Weight: | 446.50 |
| Molecular Formula: | C₂₅H₂₆N₄O₄ |
| SMILES: | N=C(C1=CC=CC(C[C@@H](C(OC)=O)[C@H](NC(C2=CC=C(C=C2)C3=CC=[N+]([O-])C=C3)=O)C)=C1)N |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | Otamixaban(FXV673) is a potent (Ki = 0.5nM), selective, rapid acting, competitive and reversible fXa inhibitor that effectively inhibits both free and prothrombinase-bound fXa. Otamixaban is a potent (Ki = 0.5nM), selective, rapid acting, competitive and reversible fXa inhibitor that effectively inhibits both free and prothrombinase-bound fXa. In vivo experiments have demonstrated that Otamixaban is highly efficacious in rodent, canine and porcine models of thrombosis. In addition, recent clinical findings indicate that Otamixaban is efficacious, safe and well tolerated in humans and therefore has considerable potential for the treatment of acute coronary syndrome. This review article chronicles the discovery and pre-clinical data surrounding the fXa inhibitor Otamixaban as well as the recent clinical findings in humans. |
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