6-OAU
Cat. No. :YN320640
CAS No. :83797-69-7
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order@ubiochem.com| Product Name: | 6-OAU |
| CAS NO.: | 83797-69-7 |
| Chemical Name: | |
| Synonyms: | |
| Molecular Weight: | 239.31 |
| Molecular Formula: | C₁₂H₂₁N₃O₂ |
| SMILES: | O=C1NC(C=C(NCCCCCCCC)N1)=O |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | 6-OAU(GTPL5846; 6-n-octylaminouracil) is a surrogate agonist of GPR84; activates human GPR84 in the presence of Gqi5 chimera in HEK293 cells with an EC50 of 105nM in the PI assay.in vitro: 6-OAU increased [35S]GTPγS incorporated in Sf9 cell membranes expressing human GPR84-Gαi fusion protein with an EC50 of 512nM. 6-OAU did not activate human GPR40 in HEK293 cells in the PI assay. Stimulation with 6.25μM 6-OAU began to induce GPR84-EGFP internalization, and the extensive internalization was observed at 200μM 6-OAU stimulation. In a Transwell assay, 3-OH-C12 and the surrogate agonist, 6-OAU, provoked chemotaxis of PMNs prepared from human peripheral blood in a concentration-dependent manner with an EC50 of 24.2μM and 318nM, respectively. In addition, 3-OH-C12 and 6-OAU increased the secretion of IL-8 from LPS-stimulated PMNs . in vivo: Injection of 6-OAU suspension in 1% rat serum into the rat jugular vein (10 mg/kg) leads to the elevation of a chemokine, CXCL1 concentration in the serum peaking at 3 h after the injection. In the rat air pouch model, 6-OAU at 1 mg/ml dissolved in 0.3% BSA attracted both PMNs and macrophages into the air pouch, peaking at 4 h after 6-OAU inoculation . |
| IC50&Target: | |
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