Chemical structure
Cat.No.
Product Name
CAS no.
Target
BRD-6929 (Cpd-60) is a brain-penetrant, selective inhibitor of HDAC1 and HDAC2(IC50= 1 and 8nM), extracted from patent US2018360927. BRD-6929 (Cpd-60) shows high-affinity to HDAC1 and HDAC2 with Kiof 0.2 ...
YN250637 Fostemsavir 864953-29-7
Fostemsavir (BMS-663068, Rukobia), the phosphonooxymethyl prodrug of BMS626529, is an attachment inhibitor that targets HIV-1 gp120 and prevents its binding to CD4+ T cells with EC50 of < 10 nM.
YN250638 Fostemsavir Tris 864953-39-9
Fostemsavir Tris (BMS-663068 (Tris)) is the phosphonooxymethyl prodrug of BMS-626529. Fostemsavir Tris (BMS-663068 (Tris)) is a novel attachment inhibitor that targetsHIV-1gp120 and prevents its binding to CD4+T cell...
YN250508 SARS-CoV-IN-2 888958-26-7
SARS-CoV-IN-2 is an effective inhibitor ofSARS-CoVreplication. SARS-CoV-IN-2 shows anti-Coronavirus activity with an EC50 of 1.9μM in Vero cells. SARS-CoV-IN-2 inhibits the 3D7 and W2 strains ofP. fa...
YN250509 SARS-CoV-IN-3 888958-27-8
SARS-CoV-IN-3 is an effective inhibitor ofSARS-CoVreplication. SARS-CoV-IN-3 shows anti-Coronavirus activity with an EC50 of 3.6μM in Vero cells. SARS-CoV-IN-3 inhibits the 3D7 and W2 strains ofP. f...
MS417 is a selective BET-specificBRD4inhibitor, binds to BRD4-BD1 and BRD4-BD2 with IC50s of 30, 46nM and Kds of 36.1, 25.4nM, respectively, with weak selectivity at CBP BRD (IC50, 32.7μM).
YN250672 Apabetalone 1044870-39-4
Apabetalone (RVX-208) is a potent BET bromodomain inhibitor with IC50 of 0.510 μM for BD2 in a cell-free assay, about 170-fold selectivity over BD1. Phase 2.
YN251729 1,3,5-Tricaffeoylquinic acid 1073897-80-9
1,3,5-Tricaffeoylquinic acid is a tricaffeoylquinic acid derivative isolated fromH. populifoliumwith anti-HIV effect.
YN250853 Etravirine D4 1142095-93-9
Etravirine D4 (TMC-125 D4) is the deuterium labeled Etravirine. Etravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV.
YN250575 Tenofovir maleate 1236287-04-9
Tenofovir Disoproxil Fumarate is anucleotide reverse transcriptase inhibitorto treat HIV and chronic Hepatitis B.
ABX464 is a novel anti-HIV molecule that inhibits HIV-1 replication in stimulated peripheral blood mononuclear cells (PBMCs) from 5 different donors with IC50 ranging between 0.1 μM and 0.5 μM.
YN251044 Sulfadoxine D3 1262770-70-6
Sulfadoxine D3 is a deuterium labeled Sulfadoxine. Sulfadoxine is a long acting sulfonamide that is used, usually in combination with other drugs, for respiratory, urinary tract and malarial infections. Sulfadoxine inhibitsHIV rep...
YN250200 3'-Azido-3'-deoxy-5-methylcyt... 1282040-14-5
3'-Azido-3'-deoxy-5-methylcytidine (CS-92) is a potent xenotropic murine leukemia-related retrovirus (XMRV) inhibitor with aCC50of 43.5μM in MCF-7 cells. 3'-Azido-3'-deoxy-5-methylcytidine also inhibitsHIV-1 reverse transc...
YN250682 Doravirine 1338225-97-0
Doravirine is a novel HIV-1 nonnucleoside reverse transcriptase inhibitor with IC50 values of 12, 9.7, and 9.7 nM against the wild type (WT) and K103N and Y181C reverse transcriptase (RT) mutants, respectively, in a biochem...
YN250295 PF-3450074 1352879-65-2
PF-3450074 (PF-74) is a specifical inhibitor ofHIV-1 capsid protein (CA) and displays a broad-spectrum inhibition of HIV isolates with submicromolar potency (EC50=8-640nM). PF-3450074 (PF-74) acts at an early stage of H...
YN250232 BRD-K98645985 1357647-78-9
BRD-K98645985 is aBAF (mammalian SWI/SNF) transcriptional repressioninhibitor with an EC50 of ~2.37 µM. BRD-K98645985 binds ARID1A-specificBAFcomplexes, prevents nucleosomal positioning, and potently reversesH...
YN250488 Lamivudine 13C,15N2 1391052-30-4
Lamivudine 13C,15N2 is a labelled impurity of Lamivudine (BCH-189). Lamivudine is a nucleoside reverse transcriptase inhibitors (NRTIs), and can inhibit HIV reverse transcriptase 1/2 and the reverse transcriptase of hepat...
YN250623 Tenofovir alafenamide hemifum... 1392275-56-7
Tenofovir alafenamide (TAF, GS-7340) hemifumarate is a prodrug of tenofovir but results in significantly higher intracellular tenofovir concentrations and lower serum levels. Tenofovir alafenamide is a novel nucleotide reverse tra...
YN250464 CDK9-IN-1 1415559-43-1
CDK9-IN-1 is a novel, selectiveCDK9inhibitor for the treatment of HIV infection, with an IC50 of 39nM for CDK9/CycT1, extracted from reference, compound 87.
YN251853 Tat-beclin 1 1423821-88-8
Tat-beclin 1, a peptide derived from a region of the autophagy protein (beclin 1), is a potent inducer ofautophagy and interacts with negative regulator of autophagy, GAPR-1 (GLIPR2). Tat-beclin 1 decreases the accumulation of p...
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