Chemical structure
Cat.No.
Product Name
CAS no.
Target
YN373857 p5 Ligand for Dnak and DnaJ 209518-24-1
p5 Lig and for Dnak and DnaJ is a nonapeptide, which corresponds to the main binding site for the 23-residue part of the presequence of mitochondrial aspartate aminotransferase. p5 Lig and for Dnak and DnaJ is a high-affinity ...
KNK437 is a pan-HSP inhibitor, which inhibits the synthesis of inducible HSPs, including HSP105, HSP72, and HSP40.
YN371329 17-GMB-APA-GA 256337-10-7
17-GMB-APA-GA is anADC Cytotoxin. 17-GMB-APA-GA is a potent HSP90 inhibitor and used for latent T. gondii infection research.
YN370333 Arimoclomol 289893-25-0
Arimoclomol (BRX-220 free base) is a co-inducer of heat shock proteins (HSP). Arimoclomol protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded assemblies via t...
YN370334 Arimoclomol maleate 289893-26-1
Arimoclomol maleate (BRX-220) is a co-inducer of heat shock proteins (HSP). Arimoclomol protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded assemblies via the...
Col003 is a selective and potent inhibitor ofHsp47 and competitively binds to the collagen binding site on Hsp47 (IC50=1.8μM). Col003 discourages the interaction of Hsp47 with collagen and inhibits collagen secretion by desta...
KRIBB11 abolishes the heat shock-induced luciferase activity with an IC50 of 1.2 μM. It is an inhibitor of the transcription factor Heat Shock Factor 1 (HSF1).
YN370335 Arimoclomol citrate 368860-21-3
Arimoclomol citrate (BRX-220 citrate) is a co-inducer of heat shock proteins (HSP). Arimoclomol citrate protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded as...
YN370894 Alvespimycin hydrochloride 467214-21-7
Alvespimycin (17-DMAG) HCl is a potent HSP90 inhibitor with IC50 of 62 nM in a cell-free assay. Phase 2.
YN371528 Aminohexylgeldanamycin 485395-71-9
Aminohexylgeldanamycin (AHGDM), a Geldanamycin derivative, is a potent HSP90 inhibitor. Aminohexylgeldanamycin shows antiangiogenic and antitumor activities.
HM03 is a potent and selectiveHSPA5(Heat shock 70kDa protein 5, also known as Bip, Grp78) inhibitor. HM03 has anticancer activity.
YN372372 VER-49009 558640-51-0
VER-49009 is aHsp90inhibitor, with an IC50 of 25nM and aKdof 78nM.
YN370236 Luminespib 747412-49-3
Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the t...
YN372370 VER-50589 747413-08-7
VER-50589 is a potent HSP90 inhibitor with IC50 of 21 nM for HSP90β.
KW-2478 is a nonansamycin HSP90 inhibitor with IC50 of 3.8 nM. Phase 1.
YN370457 VER-82576 847559-80-2
VER-82576 (NVP-BEP800) is a potent, orally available and selective Hsp90 inhibitor, with an IC50 of 58nM for Hsp90β; VER-82576 also slightly blocks Grp94 and Trap-1, with IC50s of 4.1 and 5.5μM, respectively.
BIIB021 is an orally available, fully synthetic small-molecule inhibitor of HSP90 with Ki and EC50 of 1.7 nM and 38 nM, respectively. Phase 2.
YN370231 Retaspimycin Hydrochloride 857402-63-2
Retaspimycin Hydrochloride is a potent and water-soluble inhibitor ofHsp90with EC50s of 119nM for both Hsp90 and Grp9.
YN370192 TRC051384 867164-40-7
TRC051384 is a heat shock protein 70 (HSP70) inducer.
PU-H71 is a potent and selective inhibitor of HSP90 with IC50 of 51 nM. Phase 1.
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