YN373170 Eupalinolide A 877822-40-7

Eupalinolide A, isolated fromEupatorium lindleyanum, induces the expression of HSP70 via the activation ofHSF1by inhibiting the interaction between HSF1 and HSP90.

YN373319 Kongensin A 885315-96-8

Kongensin A is a natural product isolated fromCroton kongensis. Kongensin A is an effective, covalentHSP90inhibitor that blocksRIP3-dependent necroptosishas. Kongensin A is a potentnecroptosisinhibitor and anapoptosisinducer....

YN372270 Ganetespib 888216-25-9

Ganetespib (STA-9090) is an HSP90 inhibitor with IC50 of 4 nM in OSA 8 cells, induces apoptosis of OSA cells while normal osteoblasts are not affected active metabolite of STA-1474. Phase 3.

YN370235 SNX-2112 908112-43-6

SNX-2112 (PF 04928473) is an orally activeHsp90inhibitor, with aKdof 16nM forHsp90 and IC50s of 30nM, 30nM for Hsp90 α and Hsp90 β, also induces Her-2 degradation, and inhibits Grp94 and Trap-1, with IC50s of 10 ...

YN370234 SNX-5422 908115-27-5

SNX-5422 (PF-04929113), a prodrug of SNX-2112, is an orally activeHsp90inhibitor, with aKdof 41nM, and also induces Her-2 degradation, with an IC50 of 37 nM.

YN372207 Onalespib 912999-49-6

Onalespib (AT13387) is a long-acting second-generationHsp90inhibitor with aKdof 0.71nM.

YN372264 NVP-HSP990 934343-74-5

NVP-HSP990 is a potent and selective Hsp90 inhibitor, with IC50 values of 0.6, 0.8, and 8.5nM for Hsp90α, Hsp90β, and Grp94, respectively.

YN372255 Apoptozole 1054543-47-3

Apoptozole is an inhibitor of heat shock protein 70(HSP70) and Hsc70 with dissociation constants Kd of 0.14 μM and 0.21 μM, respectively. It induces caspase-dependent apoptosis.

YN371558 Debio 0932 1061318-81-7

Debio 0932 (CUDC-305) is an orally activeHSP90inhibitor, with IC50s of 100 and 103nM for HSP90α and HSP90β, respectively.

YN370223 Gamitrinib TPP hexafluorop... 1131626-47-5

Gamitrinib TPP hexafluorophosphate is aGamitrinib (GA) mitochondrial matrixinhibitor. Gamitrinib TPP hexafluorophosphate is a mitochondrial targetedHSP90inhibitor with anti-cancer activity.

YN370456 VER-155008 1134156-31-2

VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively, >100-fold selectivity over HSP90.

YN371381 XL888 1149705-71-4

XL888 is an ATP-competitive inhibitor of HSP90 with IC50 of 24 nM. Phase 1.

YN370255 HSF1A 1196723-93-9

HSF1A is a cell-permeable heat shock transcription factor 1 (HSF1) activator. HSF1A protects cells from stress-induced apoptosis, binds TRiC subunits and inhibits TRiC activity without perturbation of ATP hydrolysis.

YN372454 NMS-E973 1253584-84-7

NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases.

YN372343 TAS-116 1260533-36-5

TAS-116 is a novel, small-molecule HSP90 inhibitor which inhibits geldanamycin-FITC binding to HSP90 proteins with Ki values of 34.7 nmol/L, 21.3 nmol/L, >50,000 nmol/L, and >50,000 nmol/L for HSP90α, HSP90β...

YN371045 HSP70-IN-1 1268273-90-0

HSP70-IN-1 is a heat shock protein (HSP) inhibitor; inhibits the growth of Kasumi-1 cells with an IC50 of 2.3μM.

YN372501 PU-WS13 1454619-14-7

PU-WS13 is a selectiveGrp94inhibitor, with an EC50 of 0.22μM.

YN370853 JG-98 1456551-16-8

JG-98 is an allosteric inhibitor of Hsp70 that binds tightly to a deep pocket that is conserved in members of the Hsp70 family.

YN371255 HS-27 1562024-11-6

HS-27, a fluorescently-tetheredHsp90inhibitor, assays surface Hsp90 expression on intact tissue specimens. HS-27 is made up of the core elements of SNX-5422, an Hsp90 inhibitor, tethered via a PEG linker to a fluorescein deriva...

YN370048 HA15 1609402-14-3

HA15 is a molecule that targets specifically BiP/GRP78/HSPA5. HA15 displays anti-cancerous activity on all melanoma cells tested, including cells isolated from patients and cells that developed resistance to BRAF inhibitors...