Parecoxib Sodium
Cat. No. :YN330344
CAS No. :198470-85-8
86-020-82000279
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order@ubiochem.com| Product Name: | Parecoxib Sodium |
| CAS NO.: | 198470-85-8 |
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| Molecular Weight: | 392.40 |
| Molecular Formula: | C₁₉H₁₇N₂NaO₄S |
| SMILES: | CCC(N([Na])S(=O)(C1=CC=C(C2=C(C)ON=C2C3=CC=CC=C3)C=C1)=O)=O |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | The prodrug Parecoxib as well as its active metabolite val have a specific affinity to the cannabinoid (CB) receptor measured in CB1-expressing HEK 293 cells and rat brain tissue. Adult male Sprague-Dawley rats were administered parecoxib (10 or 30 mg kg(-1), IP) or isotonic saline twice a day starting 24 h after middle cerebral artery occlusion (MCAO) for three consecutive days. The selective COX-2 inhibitor parecoxib was delivered 20 min before or 20 min after the incision by intraperitoneal injection. Pretreatment with parecoxib markedly attenuated the pain hypersensitivity induced by incision. |
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