Isofraxidin
Cat. No. :YN330580
CAS No. :486-21-5
86-020-82000279
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order@ubiochem.com| Product Name: | Isofraxidin |
| CAS NO.: | 486-21-5 |
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| Molecular Weight: | 222.19 |
| Molecular Formula: | C₁₁H₁₀O₅ |
| SMILES: | O=C1C=CC2=CC(OC)=C(O)C(OC)=C2O1 |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | Isofraxidin possesses significant analgesic and anti-inflammatory activities that may be mediated through the regulation of pro-inflammatory cytokines, TNF-α and the phosphorylation of p38 and ERK1/ Isofraxidin has definite anti-bacterial, anti-oxidant, and anti-inflammatory activities, it also has a protective effect against LPS-induced acute lung injury (ALI), and the protective effect of IF seems to result from the inhibition of COX-2 protein expression in the lung, which regulates the production of PGE2. Isofraxidin inhibits expression of MMP-7 and in vitro cell invasion at a non-toxic level through inhibiting ERK1/2 phosphorylation in hepatoma cell lines, which suggest isofraxidin might become an effective agent for suppressing hepatoma cell invasion. Isofraxidin is one possible radio-protector, it can protect leukemia cells from radiation-induced apoptosis via ROS/mitochondria pathway in a p53-independent manner. |
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