N-piperidine Ibrutinib hydrochloride
Cat. No. :YN430193
CAS No. :2231747-18-3
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order@ubiochem.com| Product Name: | N-piperidine Ibrutinib hydrochloride |
| CAS NO.: | 2231747-18-3 |
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| Molecular Weight: | 422.91 |
| Molecular Formula: | C₂₂H₂₃ClN₆O |
| SMILES: | NC1=C2C(N(C3CCNCC3)N=C2C4=CC=C(OC5=CC=CC=C5)C=C4)=NC=N1.[H]Cl |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | N-piperidine Ibrutinib hydrochloride (Compound 1) is a reversible Ibrutinib derivative. N-piperidine Ibrutinib hydrochloride is a potentBTKinhibitor with IC50s of 51.0 and 30.7nM for WT BTK and C481S BTK, respectively. N-piperidine Ibrutinib hydrochloride can be used as a BTK lig and in the synthesis of a series of PROTACs, such as SJF620 (HY-133137). SJF620 is a potent PROTAC BTK degrader with a DC50of 7.9nM. |
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