Cl-amidine hydrochloride
Cat. No. :YN310016
CAS No. :1373232-26-8
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order@ubiochem.com| Product Name: | Cl-amidine hydrochloride |
| CAS NO.: | 1373232-26-8 |
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| Molecular Weight: | 347.24 |
| Molecular Formula: | C₁₄H₂₀Cl₂N₄O₂ |
| SMILES: | O=C(N[C@H](C(N)=O)CCCNC(CCl)=N)C1=CC=CC=C1.[H]Cl |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | Cl-amidine hydrochloride is an orally activepeptidylarginine deminase (PAD)inhibitor, with IC50 values of 0.8μM, 6.2μM and 5.9μM for PAD1, PAD3, and PAD4, respectively. Cl-amidine hydrochloride induces apoptosis in cancer cells. Cl-amidine hydrochloride induces micro RNA (miR)-16 expression and causes cell cycle arrest. Cl-Amidine hydrochloride prevents histone 3 citrullination and neutrophil extracellular trap formation, and improves survival in a murine sepsis model . |
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