YN370039 BH3I-1 300817-68-9

BH3I-1 is a Bcl-XL-BH3 domain interaction inhibitor with Ki of 2.4 μM (by fluorescence polarization ).It is a selective inhibitor of Bcl-2 family proteins.

YN350120 L-779450 303727-31-3

L-779450 is a highly potent low nanomolar inhibitor of B-raf with IC50 of 10 nM and Kd of 2.4 nM.

YN350026 Doramapimod 285983-48-4

Doramapimod (BIRB 796) is a pan-p38 MAPK inhibitor with IC50 of 38 nM, 65 nM, 200 nM and 520 nM for p38α/β/γ/δ in cell-free assays, and binds p38α with Kd of 0.1 nM in THP-1 cells, 330-fold greater selectivity ver...

YN350065 AZ 628 878739-06-1

AZ628 is a new pan-Raf inhibitor for BRAF, BRAFV600E, and c-Raf-1 with IC50 of 105 nM, 34 nM and 29 nM in cell-free assays, also inhibits VEGFR2, DDR2, Lyn, Flt1, FMS, etc.

YN320351 Facinicline hydrochloride 677305-02-1

Facinicline hydrochloride (RG3487 hydrochloride) is an orally activenicotinic α7 receptorpartial agonist, with a Ki of 6nM for α7 human nAChR. Facinicline hydrochloride (RG3487 hydrochloride) improves cognition and sensorimot...

YN321382 Tropisetron 89565-68-4

Tropisetron is a 5-HT3 receptor antagonist and α7-nicotinic receptor agonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor.

YN350212 GDC-0879 905281-76-7

GDC-0879 is a novel, potent, and selective B-Raf inhibitor with IC50 of 0.13 nM in A375 and Colo205 cells with activity against c-Raf as well no inhibition known to other protein kinases.

YN321716 Pectolinarin 28978-02-1

Pectolinarin, isolated fromCirsium chanroenicum, possesses anti-inflammatory activity. Pectolinarin inhibits secretion ofIL-6 and IL-8, as well as the production ofPGE2 and NO. Pectolinarin suppresses cell proliferation and i...

YN350185 Ro 5126766 946128-88-7

RO5126766 (CH5126766) is a dual RAF/MEK inhibitor with IC50 of 8.2 nM,19 nM, 56 nM, and 160 nM for BRAF V600E, BRAF, CRAF, and MEK1, respectively. Phase 1.

YN320091 Cinanserin hydrochloride 54-84-2

Cinanserin hydrochloride (SQ 10643) is a potent, selective and highly affinity 5-HT2 receptorantagonist with a Ki of 41nM. Cinanserin hydrochloride has a much higher binding affinity for the5-HT2than for the 5-HT1receptor (Ki...

YN321570 Ramatroban 116649-85-5

Ramatroban (BAY u 3405) is a thromboxane A2(TxA2) receptor antagonist with Ki value of 10 to 13 nM. It also antagonizes a newly identified PGD2 receptor, CRTh2 expressed on the inflammatory cells.

YN321149 Atenolol 29122-68-7

Atenolol is a selective β1 receptor antagonist with log Kd values of ?6.66±0.05, ?5.99±0.14, ?4.11±0.07 for binding to the human β1-, β2- and β3-adrenoceptors.