YN350154 Agerafenib 1188910-76-0

CEP-32496 is a highly potent inhibitor of BRAF(V600E/WT) and c-Raf with Kd of 14 nM/36 nM and 39 nM, also potent to Abl-1, c-Kit, Ret, PDGFRβ and VEGFR2, respectively insignificant affinity for MEK-1, MEK...

YN321663 Alprenolol hydrochloride 13707-88-5

Alprenolol hydrochloride is the hydrochloride salt form of alprenolol, which is an beta adrenergic receptorantagonist and is used as an antihypertensive, anti-anginal, and anti-arrhythmic agent.

YN320094 Spiramide 510-74-7

Spiramide (AMI-193) is a potent and selective antagonist of5-HT2 and dopamine D2 receptor, with Kis of 2nM and 3nM, respectively. Spiramide has >2000-fold selectivity for 5-HT2versus5-HT1C(Ki=4300nM) receptors. Spiramid...

YN320055 Flopropione 2295-58-1

Flopropione is a spasmolytic or antispasmodic agent, and acts as a 5-HT1A receptor antagonist.

YN340104 ZM39923 hydrochloride 1021868-92-7

ZM 39923 HCl is an JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR also found to be sensitive to transglutaminase.

YN320882 Quetiapine 111974-69-7

Quetiapine is an atypical antipsychotic used for the treatment of schizophrenia, bipolar disorder, and major depressive disorder.

YN320446 8-OH-DPAT 78950-78-4

8-OH-DPAT is a potent and selective5-HTagonist, with apIC50 of 8.19 for 5-HT1A and a Ki of 466nM for 5-HT7; 8-OH-DPAT weakly binds to 5-HT1B (pIC50, 5.42), 5-HT (pIC50<5).

YN321377 Lurasidone 367514-87-2

Lurasidone is a second-generation antipsychotic agent that exhibits full antagonism at dopamine D2 and serotonin 5-HT2A receptors with binding affinities Ki = 1 nM and Ki = 0.5 nM, respectively. It also has high affinity for serot...

YN350104 BRD7389 376382-11-5

BRD7389 is a specificRSKfamily kinase inhibitor with IC50s of 1.5μM, 2.4μM, and 1.2μM forRSK1,RSK2, and RSK3, respectively. BRD7389 is a small-molecule inducer of insulin expression in pancreatic α-cells.

YN350053 Guggulsterone 95975-55-6

Guggulsterone is one of the active constituent of Commiphora mukul. It occurs in two isomeric forms, namely Z-GS and E-GS. Guggulsterone act as antagonist ligands for the bile acid receptor, farnesoid X receptor, and as active in...

YN321594 Pindolol 13523-86-9

Pindolol (LB-46) is a nonselective β-blocker with partial beta-adrenergic receptor agonist activity, also functions as a 5-HT1A receptor weak partial antagonist (Ki=33nM).

YN320273 AH 6809 33458-93-4

AH 6809 is an antagonist ofEP and DP receptor, with a Ki of 1217, 1150, 1597, and 1415nM for the clonedhuman EP1,EP2,EP3-III, and DP receptorrespectively, and with a Ki of 350nM formouse EP2receptor .