YN321629 Trimipramine maleate 521-78-8

Trimipramine maleate is a 5-HT receptor antagonist, with pKis of 6.39, 8.10, 4.66 for 5-HT1C, 5-HT2 and 5-HT1A, respectively.

YN310090 TCS 21311 1260181-14-3

TCS 21311 (NIBR3049) is a potent, highly selectiveJAK3inhibitor with an IC50 of 8nM, it displays >100-fold selectivity over JAK1, JAK2 and TYK2. TCS 21311 (NIBR3049) inhibitsPKCα,PKCθ, and GSK3βwi...

YN350133 CKI-7 free base 120615-25-0

CKI-7 free base is a potent and ATP-competitivecasein kinase 1 (CK1)inhibitor with an IC50 of 6μM and a Ki of 8.5μM. CKI-7 free base is a selectiveCdc7 kinaseinhibitor. CKI-7 free base also inhibitsSGK,ribosomal...

YN330154 ANI-7 931417-26-4

ANI-7 is an activator ofaryl hydrocarbon receptor (AhR)pathway. ANI-7 inhibits the growth of multiple cancer cells, and potently and selectively inhibits the growth of MCF-7 breast cancer cells with a GI50of 0.56μM. ANI...

YN310181 A-3 hydrochloride 78957-85-4

A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of variouskinases. It against PKA (Ki=4.3 µM), casein kinase II (Ki=5.1 µM) and myosin light chain kinase (MLCK) (Ki=...

YN340104 ZM39923 hydrochloride 1021868-92-7

ZM 39923 HCl is an JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR also found to be sensitive to transglutaminase.

YN330514 Ginsenoside Rd 52705-93-8

Ginsenoside Rd, a minor ginseng saponin, has several pharmacological activities such as immunosuppressive activity, anti-inflammatory activity, immunological adjuvant, anti-cancer activity and wound-healing activity.

YN350169 PF-4708671 1255517-76-0

PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) with Ki/IC50 of 20 nM/160 nM in cell-free assays, 400-fold greater selectivity for S6K1 than S6K2, and 4- and >20-fold selectivity for S6K1 t...

YN310259 Staurosporine 62996-74-1

Staurosporine (CGP 41251) is a potent PKC inhibitor for PKCα, PKCγ and PKCη with IC50 of 2 nM, 5 nM and 4 nM, less potent to PKCδ (20 nM), PKCε (73 nM) and little active to PKCζ (1086 nM)...