YN330416 Disulfiram 97-77-8

Disulfiram is a specific inhibitor of aldehyde-dehydrogenase (ALDH1), used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol.

YN330637 Negletein 29550-13-8

Negletein is a neuroprotectant enhances the action of nerve growth factor and induces neurite outgrowth in PC12 cells. Negletein shows promising anti-inflammatory activity via inhibition ofTNF-α and IL-1βwith IC50 values of 1...

YN330562 Madecassic acid 18449-41-7

Madecassic acid, a natural triterpene first isolated from C. asiatica, has diverse anti-inflammatory and anti-diabetic effects, blocking NF-κB activation in macrophages and altering lipid metabolism in mice, at least in part through a...

YN330233 YQ128 2454246-18-3

YQ128 is a potent and selective second-generationNLRP3 (NOD-like receptor P3) inflammasomeinhibitor with an IC50 of 0.30 µM. YQ128 significantly and selectively suppresses the production ofIL-1β, but not TNF-α, a...

YN330513 Ginsenoside Rc 11021-14-0

Ginsenoside Rc, one of major Ginsenosides fromPanax ginseng, enhances GABA receptorA(GABAA)-mediated ion channel currents (IGABA). Ginsenoside Rc inhibits the expression ofTNF-α and IL-1β.

YN330569 Mulberroside A 102841-42-9

Mulberroside A is one of the main bioactive constituent in mulberry (Morus albaL.). Mulberroside A decreases the expressions ofTNF-α,IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and ...

YN330576 Neochlorogenic acid 906-33-2

Neochlorogenic acid has outstanding antioxidant, antibacterial, antiviral, and antipyretic activities, it also exerts neuroprotective effects through the inhibition of pro-inflammatory pathways in activated microglia. Neochlorogenic aci...

YN330536 Diacerein 13739-02-1

Diacerein is an inhibitor of pro-inflammatory cytokine Interleukin-1B (IL-1B) production, prescribed for osteoarthritis and chronic inflammatory arthritis.