YN340022 NSC 228155

NSC228155 is an activator of EGFR. It binds to the sEGFR dimerization domain II and modulates EGFR tyrosine phosphorylation.

YN340183 WHI-P180 211555-08-7

WHI-P180 is a multi-kinase inhibitor with IC50 values of 4.5 and 66 nM for the human proto-oncogene RET and kinase insert domain receptor (KDR) , respectively.

YN340022 NSC 228155 113104-25-9

NSC228155 is an activator of EGFR. It binds to the sEGFR dimerization domain II and modulates EGFR tyrosine phosphorylation.

YN310360 Paris saponin VII 68124-04-9

Chonglou Saponin VII, a kind of steroidal saponins from Chonglou (Rhizoma Paridis Chonglou), inhibits EMT and reduces the invasion of ovarian cancer cells via the GSK-3β/β-catenin signaling pathway.

YN310285 Inauhzin 309271-94-1

Inauhzin is a cell-permeable SIRT1 inhibitor with an IC50 of 0.7-2 μM and reactivates p53 by inhibiting SIRT1 deacetylation activity.

YN320826 Veliflapon 128253-31-6

Veliflapon (BAY X 1005; DG-031) is an orally active and selective5-lipoxygenase activating protein (FLAP)inhibitor. Veliflapon inhibits the synthesis of theleukotrienes B4 and C4.

YN330568 Ginsenoside Rh1 63223-86-9

Ginsenoside Rh1 is isolated from the root of Panax Ginseng. Ginsenoside Rh1 inhibits the expression of PPAR-γ, TNF-α, IL-6, and IL-1β.

YN330012 C29 363600-92-4

TLR2-IN-C29 (C29) is a Toll-like receptor 2 (TLR2) inhibitor that inhibits TLR2/1 and TLR2/6 signaling.

YN350023 SB 203580 152121-47-6

SB203580 is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM in THP-1 cells, 10-fold less sensitive to SAPK3(106T) and SAPK4(106T) and blocks PKB phosphorylation with IC50 of 3-5 μM.

YN370010 KNK437 218924-25-5

KNK437 is a pan-HSP inhibitor, which inhibits the synthesis of inducible HSPs, including HSP105, HSP72, and HSP40.

YN330148 Sparstolonin B 1259330-61-4

Sparstolonin B acts as a selectiveTLR2 and TLR4antagonist and selectively blocks TLR2- and TLR4-mediated inflammatory signaling. Sparstolonin B has anti-HIV and anticancer activities.

YN330101 CU-T12-9 1821387-73-8

CU-T12-9 is a specificTLR1/2agonist withEC50of 52.9nM in HEK-Blue hTLR2 SEAP assay. CU-T12-9 activates both the innate and the adaptive immune systems. CU-T12-9 selectively activates the TLR1/2 heterodimer, no...

YN370455 Pifithrin-μ 64984-31-2

Pifithrin-μ is a specific p53 inhibitor by reducing its affinity to Bcl-xL and Bcl-2, and also inhibits HSP70 function and autophagy.

YN310294 Resveratrol 501-36-0

Resveratrol has a wide spectrum of targets including cyclooxygenases(i.e. COX, IC50=1.1 μM), lipooxygenases（LOX, IC50=2.7 μM）, kinases, sirtuins and other proteins. It has anti-cancer, anti-inflammatory, blood-sugar-loweri...

YN350024 SB 203580 hydrochloride 869185-85-3

SB 203580 hydrochloride (RWJ 64809 hydrochloride) is a selective and ATP-competitivep38 MAPKinhibitor with IC50s of 50nM and 500nM forSAPK2a/p38 and SAPK2b/p38β2, respectively. SB 203580 hydrochloride inhibits...