YN350079 UM-164 903564-48-7

UM-164 is a highly potent, dual c-Src/p38inhibitor of c-Src with a binding constant Kd of 2.7 nM for c-Src and inhibits both p38α and p38β.

YN320203 FITM 932737-65-0

FITM is a negative allosteric modulator ofmGlu1receptor with a Ki of 2.5nM.

YN320037 E4CPG 170846-89-6

E4CPG is a group I/group II metabotropic glutamate receptor antagonist, more potent than (RS)-MCPG .

YN321288 LY404039 635318-11-5

LY404039 is a potent agonist of recombinant human mGlu2/mGlu3 receptors with Ki of 149 nM/92 nM, shows >100-fold selectivity over ionotropic glutamate receptors, glutamate transporters, and other receptors. Phase 3.

YN320056 VU0364770 61350-00-3

VU0364770 is a selective and potent positive allosteric modulator (PAM) ofmGlu4. VU0346770 exhibitsEC50s of 290nM and 1.1μM atrat mGlu4 and human mGlu4 receptor, respectively. VU0364770 exhibits antagonist activity at m...

YN320043 (S)-MCPG 150145-89-4

(S)-MCPG ((+)-MCPG) is a potentgroup I/II metabotropic glutamate receptor (mGluRs)antagonist and the active isomer of (RS)-MCPG (HY-100371). (S)-MCPG can be used for the study of the function of mGluRs in spa...

YN321230 JNJ-46778212 1363281-27-9

JNJ-46778212 (VU 0409551) is anmGlu5positive allosteric modulator with an EC50 of 260nM.

YN320989 CTEP 871362-31-1

CTEP (RO4956371) is a novel, long-acting, orally bioavailable allosteric antagonist of mGlu5 receptor with IC50 of 2.2 nM, shows >1000-fold selectivity over other mGlu receptors.

YN320035 Lu AF21934 1445605-23-1

Lu AF21934 is a selective and brain-penetrantm Glu4receptor positive allosteric modulator with an EC50 of 500nM for mGlu4 receptor.

YN320621 DHPG 146255-66-5

DHPG ((RS)-3,5-DHPG) is an amino acid, which acts as a selective and potent agonist ofgroup I mGluR(mGluR 1 and mGluR 5), shows no effect on Group II or Group III mGluRs. DHPG ((RS)-3,5-DHPG) is also ...

YN350040 Talmapimod 309913-83-5

Talmapimod (SCIO-469) is an orally active, selective, and ATP-competitivep38αinhibitor with an IC50 of 9nM. Talmapimod shows about 10-fold selectivity over p38β, and at least 2000-fold selectivity over a panel of 20 other ...

YN330168 PD98059 167869-21-8

PD98059 is a non-ATP competitive MEK inhibitor with IC50 of 2 μM in a cell-free assay, specifically inhibits MEK-1-mediated activation of MAPK does not directly inhibit ERK1 or ERK2.

YN350093 U0126-EtOH 1173097-76-1

U0126-EtOH is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM in cell-free assays, 100-fold higher affinity for ΔN3-S218E/S222D MEK than PD98059.

YN350025 SB 202190 152121-30-7

SB202190 (FHPI) is a potent p38 MAPK inhibitor targeting p38α/β with IC50 of 50 nM/100 nM in cell-free assays, sometimes used instead of SB 203580 to investigate potential roles for SAPK2a/p38 in vivo.

YN330458 Fenofibric acid 42017-89-0

Fenofibric acid is a fibrate that acts as a lipid-lowering agent, decreasing low-density lipoprotein cholesterol and triglycerides.