YN340146 BDTX-189

BDTX-189 is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations with Kd of 0.2 nM, 0.76 nM, 13 nM and 1.2 nM for EGFR, HER2, BLK and RIPK2, reapectively....

YN340146 BDTX-189 2414572-47-5

BDTX-189 is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations with Kd of 0.2 nM, 0.76 nM, 13 nM and 1.2 nM for EGFR, HER2, BLK and RIPK2, reapectively....

YN310321 MN-64 92831-11-3

MN-64 is a potent inhibitor of TNKS1 and TNKS2 with IC50 value of 6 and 72 nM, respectively.

YN321302 CCG-63802 620112-78-9

CCG-63802 is a reversible inhibitor of regulator of G-protein signaling (RGS) protein; with greatest potency at RGS4. CCG-63802 is selective amongst RGS proteins, with greatest potency at RGS4. CCG-63802 inhibits GTP...

YN310223 AZD-2461 1174043-16-3

AZD2461 is a novel PARP inhibitor with low affinity for Pgp than Olaparib. Phase 1.

YN360394 ML204 hydrochloride 2070015-10-8

ML204 hydrochloride is a novel, potent, selectiveTRPC4/TRPC5channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, o...

YN360393 ML204 5465-86-1

ML204 is a novel, potent, and selective TRPC4 channel inhibitor with apparent IC50 values of about 1 μM in fluorescent intracellular Ca2+ assays and about 3 μM in whole-cell voltage clamp experiments. It exhibits some selectiv...

YN320879 Ziprasidone 146939-27-7

Ziprasidone, an antipsychotic agent, is a combined5-HT (serotonin) and dopamine receptorantagonist. Ziprasidone has high affinity for rat (Ki: 3.4nM)/human (2.5nM) 5-HT1A receptors, 5-HT2A (0.42nM), and dopamine D2 receptor...

YN370456 VER-155008 1134156-31-2

VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively, >100-fold selectivity over HSP90.

YN321006 APD668 832714-46-2

APD668 is a potent GPR119 agonist with EC50s of 2.7 and 33 nM for human and rat forms, respectively.

YN360615 Rosiglitazone 122320-73-4

Rosiglitazone is a potent antihyperglycemic agent and a potent thiazolidinedione insulin sensitizer with IC50 of 12, 4 and 9 nM for rat, 3T3-L1 and human adipocytes, respectively. Rosiglitazone is a pure ligand of PPAR-gamma, and...