YN330596 Ginsenoside Rg5

Ginsenoside Rg5 is the main component of Red ginseng. Ginsenoside blocks binding ofIGF-1to its receptor with an IC50 of ~90nM. Ginsenoside Rg5 also inhibits the mRNA expression ofCOX-2via suppression of the DNA binding ...

YN330596 Ginsenoside Rg5 186763-78-0

Ginsenoside Rg5 is the main component of Red ginseng. Ginsenoside blocks binding ofIGF-1to its receptor with an IC50 of ~90nM. Ginsenoside Rg5 also inhibits the mRNA expression ofCOX-2via suppression of the DNA binding ...

YN340153 Napabucasin 83280-65-3

Napabucasin is an orally available Stat3 and cancer cell stemness inhibitor.

YN340027 STAT5-IN-1 285986-31-4

STAT5-IN-1 is a potent and selective STAT5 inhibitor with IC50 of 47 μM for STAT5β isoform.

YN340162 Homoharringtonine 26833-87-4

Homoharringtonine is a cytotoxic alkaloid, induces apoptosis and inhibits STAT3 via IL-6/JAK1/STAT3 signal pathway in Gefitinib-resistant lung cancer cells.

YN340260 Artesunate 88495-63-0

Artesunate is a part of the artemisinin group of agents with an IC50 of < 5 μM for small cell lung carcinoma cell line H69. It is a potential inhibitor of STAT-3 and exhibits selective cytotoxicity of cancer cells over normal cel...

YN340075 C188-9 432001-19-9

C188-9 is a potent inhibitor of STAT3 that binds to STAT3 with high affinity (KD=4.7±0.4 nM). C188-9 is well tolerated in mice, shows good oral bioavailability, and is concentrated in tumors.

YN320787 AZ12672857 945396-55-4

AZ12672857 is an orally active inhibitor ofEphB4(IC50=1.3nM) and Src kinases. AZ12672857 shows good inhibition of proliferation of c-Src transfected 3T3 cells (IC50=2nM) as well as autophosphorylation of EphB4 in transfect...

YN330154 ANI-7 931417-26-4

ANI-7 is an activator ofaryl hydrocarbon receptor (AhR)pathway. ANI-7 inhibits the growth of multiple cancer cells, and potently and selectively inhibits the growth of MCF-7 breast cancer cells with a GI50of 0.56μM. ANI...

YN340284 Garcinone C 76996-27-5

Garcinone C, a xanthone derivative, is a natural compound extracted fromGarcinia oblongifolia Champthat is used as an anti-inflammatory, analgesia, astringency and granulation-promoting medicine, and has potential cytotoxic effects ...

YN340014 STAT3-IN-1 2059952-75-7

STAT3-IN-1 (compound 7d) is an excellent, selective and orally active inhibitor of STAT3 with IC50 of 1.82 μM and 2.14 μM in HT29 and MDA-MB 231 cells, respectively. STAT3-IN-1 induces apoptosis of tumor cells.

YN340010 HJC0152 hydrochloride 1420290-99-8

HJC0152 is a signal transducer and activator of transcription 3 (STAT3) inhibitor with remarkably improved aqueous solubility.

YN340114 STAT3-IN-3 2361304-26-7

STAT3-IN-3 is a potent and selective inhibitor ofsignal transducer and activator of transcription 3 (STAT3), with anti-proliferative activity. STAT3-IN-3 inducesapoptosisin breast cancer cells. STAT3-IN-3 acts as a...

YN340033 STAT5-IN-2 2111834-61-6

STAT5-IN-2 is aSTAT5inhibitor with EC50s of 9μM and 5μM in K562 and KU812 cells, respectively. Potent antileukemic effect.

YN340274 Mogrol 88930-15-8

Mogrol is a biometabolite of mogrosides, and acts via inhibition of theERK1/2 and STAT3pathways, or reducingCREBactivation and activatingAMPKsignaling.