YN410031 TBK1/IKKε-IN-2 1292310-49-6

TBK1/IKKε-IN-2 is a dual inhibitor of TBK1 and IKKε.

YN410078 AZD3264 1609281-86-8

AZD3264 is a novel IKK2 inhibitor.

YN410036 TBK1/IKKε-IN-5 1893397-65-3

TBK1/IKKε-IN-1 (compound 1) is a dual inhibitor of TANK-binding kinase 1 (TBK1) and IκB kinase-ε (IKKε/IKK-i) with IC50 of 1.0 nM and 5.6 nM for TBK1 and IKKε, respectively. TBK1/IKK...

YN410154 TBK1/IKKε-IN-1 2058264-32-5

TBK1/IKKε-IN-1 is a dualTBK1 and IKKεinhibitor extracted from patent US20160376283 A1, Compound 274 in Example 60, hasIC50s of <100nM.

YN410017 GSK8612 2361659-62-1

GSK8612 is a highly potent and selective inhibitor for TBK1 (Tank-binding Kinase-1) with pKd of 8.0. Within 10-fold affinity with respect to TBK1, no off-targets of GSK8612 could be identified.

YN410046 BAY-985 2409479-29-2

BAY-985 is a highly potent, orally active and selective ATP-competitive dual inhibitor of TBK1 and IKKεwith IC50s of 2/30 and 2nM for TBK1 (low/high ATP) and IKKε, respectively. Antitumor efficacy.