TBK1/IKKε-IN-5
Cat. No. :YN410036
CAS No. :1893397-65-3
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order@ubiochem.com| Product Name: | TBK1/IKKε-IN-5 |
| CAS NO.: | 1893397-65-3 |
| Chemical Name: | |
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| Molecular Weight: | 513.59 |
| Molecular Formula: | C₂₈H₃₁N₇O₃ |
| SMILES: | N#CC1=CC(C2=NC(NC3=CC=C(N4CCN(C5COC5)CC4)C=C3)=NC=N2)=CC=C1OC6CCOCC6 |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | TBK1/IKKε-IN-1 (compound 1) is a dual inhibitor of TANK-binding kinase 1 (TBK1) and IκB kinase-ε (IKKε/IKK-i) with IC50 of 1.0 nM and 5.6 nM for TBK1 and IKKε, respectively. TBK1/IKKε inhibition enhances response to PD-1 blockade, which effectively predicts tumor response in vivo. |
| IC50&Target: | |
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