Chemical structure
Cat.No.
Product Name
CAS no.
Target
YN420324 AKTide-2T 324029-01-8
AKTide-2T is an excellent in vitro substrate forAKT and shows competitive inhibition of histone H2B phosphorylation with a Ki of 12nM. AKTide-2T mimics the optimal phosphorylation sequence of Akt and is an inhibitory pept...
SU 6656 is a selective Src family kinase inhibitor with IC50 of 280 nM, 20 nM, 130 nM, and 170 nM for Src, Yes, Lyn, and Fyn, respectively.
YN420027 Recilisib 334969-03-8
Recilisib is a radioprotectant, which can activateAKT,PI3Kactivities in cells.
A-443654 is apan-Aktinhibitor and has equal potency againstAkt1,Akt2, orAkt3within cells (Ki=160 pM).
DB07107 is a potent drug resistantT315I mutant Bcr-Abl tyrosine kinaseinhibitor. DB07107 is also a potentAkt1inhibitor with an IC50 value of 360nM.
YN420040 AKT inhibitor VIII 612847-09-3
Akti-1/2 is a highly selective Akt1/Akt2 inhibitor with IC50 of 58 nM/210 nM, respectively, about 36-fold selectivity for Akt1 over Akt3.
YN420035 AKT Kinase Inhibitor 842148-40-7
AKT Kinase Inhibitor is anAktkinase inhibitor with anti-tumor activity.
SC66 is an allosteric inhibitor which displays a dual-inhibitory function toward AKT activity with IC50 values of 0.77, 2.85 and 0.47 μg/ml in HepG2, Huh7 and Hep3B cells after 72 h treatment, respectively.
YN420156 CCT128930 885499-61-6
CCT128930 is a potent, ATP-competitive and selective inhibitor of Akt2 with IC50 of 6 nM in a cell-free assay, 28-fold greater selectivity for Akt2 than the closely related PKA kinase.
YN420276 Akt1 and Akt2-IN-1 893422-47-4
Akt1 and Akt2-IN-1 is an allosteric inhibitor of Akt1(IC50=3.5nM) and Akt2(IC50=42nM), with potent and balanced activity.
FPA-124, a cell-permeable copper complex, is a selectiveAktinhibitor with an IC50 of 0.1μM. FPA-124 interacts with both the pleckstrin homology (PH) and the kinase domains of Akt. FPA-124 inducesapoptosis.
YN420034 GSK-690693 937174-76-0
GSK-690693 is an ATP-competitivepan-Aktinhibitor with IC50s of 2nM, 13nM, 9nM forAkt1,Akt2 and Akt3, respectively. GSK-690693 is also anAMPKinhibitor, affects Unc-51-like autophagy activating kinase 1 (ULK1) activi...
YN420200 Ipatasertib 1001264-89-6
Ipatasertib (GDC-0068) is a highly selective pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 5 nM/18 nM/8 nM in cell-free assays, 620-fold selectivity over PKA. Phase 2.
YN420056 PF-AKT400 1004990-28-6
PF-AKT400 is a broadly selective, potent, ATP-competitiveAktinhibitor, displays 900-fold greater selectivity forPKBα(IC50=0.5nM) thanPKA(IC50=450nM).
YN420041 MK-2206 dihydrochloride 1032350-13-2
MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM in cell-free assays, respectively no inhibitory activities against 250 other protein kinases observed. Phase 2.
YN420230 Uprosertib 1047634-65-0
Uprosertib (GSK2141795) is a selective, ATP-competitive, and orally bioavailable Akt inhibitor with IC50 of 180 nM, 328 nM, and 38 nM for Akt 1, 2 and 3, respectively. Phase 2.
YN420231 Uprosertib hydrochloride 1047635-80-2
Uprosertib hydrochloride (GSK2141795 hydrochloride) is a potent and selectivepan-Aktinhibitor with IC50 values of 180/328/38nM for Akt1/Akt2/Akt3, respectively.
YN420213 Capivasertib 1143532-39-1
AZD5363 potently inhibits all isoforms of Akt(Akt1/Akt2/Akt3) with IC50 of 3 nM/8 nM/8 nM in cell-free assays, similar to P70S6K/PKA and lower activity towards ROCK1/2. Phase 2.
PHT-427 is a dual Akt and PDPK1 inhibitor (high affinity binding for the PH domains of Akt and PDPK1) with Ki of 2.7 μM and 5.2 μM, respectively.
K-80003 is a potent inhibitor of tRXRα-dependentAktactivation and cancer cell growth.
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