Macelignan
Cat. No. :YN251438
CAS No. :107534-93-0
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order@ubiochem.com| Product Name: | Macelignan |
| CAS NO.: | 107534-93-0 |
| Chemical Name: | |
| Synonyms: | |
| Molecular Weight: | 328.40 |
| Molecular Formula: | C₂₀H₂₄O₄ |
| SMILES: | OC1=CC=C(C[C@H](C)[C@H](C)CC2=CC=C(OCO3)C3=C2)C=C1OC |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | Macelignan(Anwuligan) is a natural compound isolated from Myristica fragrans Houtt; possesses therapeutic potentials against neurodegenerative diseases with oxidative stress and neuroinflammation. in vitro: Macelignan significantly attenuated the ROS production and neurotoxicity induced by glutamate in HT22 cell . At 24 h of biofilm growth, S. mutans, A. viscosus and S. sanguis biofilms were reduced by up to 30%, 30% and 38%, respectively, after treatment with 10 microg/mL macelignan for 5 min . Cisplatin-induced phosphorylation of c-Jun N-terminal kinase1/2 (JNK1/2) and extracellular signal-regulated kinase1/2 (ERK1/2) was abrogated by pretreatment with macelignan, however, that of p38 was not significantly affected . in vivo: Macelignan attenuated the expression of phosphorylated c-Jun in cisplatin-treated mice . Daily administration of macelignan reduced the spatial memory impairments induced by the chronic LPS infusions . |
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