LY2811376
Cat. No. :YN380026
CAS No. :1194044-20-6
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order@ubiochem.com| Product Name: | LY2811376 |
| CAS NO.: | 1194044-20-6 |
| Chemical Name: | |
| Synonyms: | |
| Molecular Weight: | 320.36 |
| Molecular Formula: | C₁₅H₁₄F₂N₄S |
| SMILES: | FC1=C(C2=CN=CN=C2)C=C([C@]3(C)CCSC(N3)=N)C(F)=C1 |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | LY2811376 is the first orally available non-peptidic β-secretase(BACE1) inhibitor with IC50 of 239 nM-249 nM, that act to decrease Aβ secretion with EC50 of 300 nM, demonstrated to have 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including cathepsin D, pepsin, or renin. Phase 1. |
| IC50&Target: | |
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