YN321274 Mavorixafor 558447-26-0

Mavorixafor (AMD-070) is a potent, selective and orally availableCXCR4antagonist, with an IC50 value of 13nM against CXCR4125I-SDF binding, and also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in M...

YN321794 Motixafortide 664334-36-5

Motixafortide (BL-8040, BKT140, TF 14016, 4-fluorobenzoyl, 4F-benzoyl-TN14003, T140) is an antagonist of CXCR4 with IC50 of ～1 nM. BL-8040 induces the apoptosis of AML blasts by down-regulating ERK, BCL-2, MC...

YN320964 NBI-74330 855527-92-3

NBI-74330 is a potent antagonist forCXCR3, and exhibits potent inhibition of (125I)CXCL10 and (125I)CXCL11 specific binding with Kiof 1.5 and 3.2nM, respectively.

YN321250 AZD-5069 878385-84-3

AZD-5069 is a novel antagonist of CXCR2, which is shown to inhibit binding of CXCL8 to CXCR2 with a pIC50 value of 8.8 and inhibit CXCL8 binding to CXCR1 with pIC50 values of 6.5.

YN320789 MSX-122 897657-95-3

MSX-122 is a novel small molecule and partial CXCR4 antagonist (IC50~10 nM).

YN320013 SCH 546738 906805-42-3

SCH 546738 is a potent, orally active and non-competitiveCXCR3antagonist, the affinity constant (Ki) of SCH 546738 binding to human CXCR3 receptor is determined to be 0.4nM in multiple experiments.

YN320808 AZD8797 911715-90-7

AZD8797 is an allosteric non-competitive and orally active antagonist of the humanCX3CR1receptor; antagonizes CX3CR1 and CXCR2 with Kis of 3.9 and 2800nM, respectively.

YN320429 PS372424 914291-61-5

PS372424, a three amino-acid fragment of CXCL10, is a specific humanCXCR3agonist with anti-inflammatory activity. PS372424 prevents human T-cell migration in a humanized model of arthritic inflammation.

YN321245 Danirixin 954126-98-8

Danirixin is a selective, and reversibleCXCR2antagonist, with IC50 of 12.5nM for CXCL8.

YN321066 UNBS5162 956590-23-1

UNBS5162 is a pan-antagonist ofCXCL chemokineexpression, with anti-tumor activity.

YN321182 Elubrixin tosylate 960495-43-6

Elubrixin tosylate (SB-656933 tosylate) is a potent, selective, competitive, reversible and orally activeCXCR2antagonist and anIL-8 receptorantagonist. Elubrixin tosylate inhibits neutrophil CD11b upregulation (IC50 of 260...

YN320445 NUCC-390 1060524-97-1

NUCC-390 is a novel and selective small-moleculeCXCR4 receptoragonist. NUCC-390 induces internalization of CXCR4 receptors and acts in an opposite way of AMD3100 (HY-10046). NUCC-390 promotes nerve recovery of f...

YN320602 LY2510924 1088715-84-7

LY2510924 is a potent and selectiveCXCR4antagonist that blocks SDF-1 binding to CXCR4 with an IC50 of 0.079nM.

YN320148 IT1t dihydrochloride 1092776-63-0

IT1t dihydrochloride is a potentCXCR4antagonist; inhibits CXCL12/CXCR4 interaction with an IC50 of 2.1nM.

YN321252 Burixafor hydrobromide 1191450-19-7

Burixafor hydrobromide (TG-0054 hydrobromide) is an orally bioavailable and potent antagonist ofCXCR4 and a well water soluble anti-angiogenic drug that is of potential value in treating choroid neovascularization. Burixafor hydr...

YN320993 SRT3109 1204707-71-0

SRT3109 is an antagonist ofCXCR2, with apIC50 of 8.2, and used in the research of chemokine mediated diseases.

YN320682 SRT3190 1204707-73-2

SRT3190 is an antagonist ofCXCR2, used in the research of chemokine mediated diseases.

YN320479 USL311 1373268-67-7

USL311 is a selectiveCXCR4antagonist, with anti-tumor activity. USL311 prevents the binding of stromal-cell derived factor-1 (SDF-1 or CXCL12) to CXCR4.

YN320430 PS372424 hydrochloride 1596362-29-6

PS372424 hydrochloride, a three amino-acid fragment of CXCL10, is a specific humanCXCR3agonist with anti-inflammatory activity. PS372424 hydrochloride prevents human T-cell migration in a humanized model of arthritic inflammati...

YN320523 SX-682 1648843-04-2

SX-682 is an orally bioavailable small-molecule allosteric inhibitor of CXCR1 and CXCR2 that blocks tumor MDSC recruitment and enhances T cell activation and antitumor immunity.