YN350211 SCH772984 942183-80-4

SCH772984 is a highly selective and ATP-competitive ERK inhibitor, with IC50s of 4 and 1nM for ERK1 and ERK2, respectively. SCH772984 has antitumor activity in MAPK inhibitor-naïve and MAPK inhibitor-re...

YN350070 MK-8353 1184173-73-6

MK-8353 (SCH900353) is an orally bioavailable, selective, and potent ERK inhibitor that inhibits activated ERK1 and ERK2 in vitro, with IC50 values of 23.0 nM and 8.8 nM, respectively (IMAP kinase assay), and no...

YN350145 ERK5-IN-1 1234479-76-5

ERK5-IN-1 is a potentERK5inhibitor with an IC50 of 87±7nM. ERK5-IN-1 also inhibitsLRRK2[G2019S] with an IC50 of 26nM.

YN350146 XMD8-92 1234480-50-2

XMD8-92 is a potent and selective BMK1/ERK5 inhibitor with Kd of 80 nM.

YN350098 BIX02189 1265916-41-3

BIX02189 is a potent and selectiveMEK5inhibitor with an IC50 of 1.5nM. BIX02189 also inhibitsERK5catalytic activity with an IC50 of 59nM.

YN350183 Longdaysin 1353867-91-0

Longdaysin is a Casein Kinase inhibitor with IC50 values of 8.8 μM, 5.6 μM, 52 μM and 29 μM for CKIδ, CKIα, ERK2 and CDK7.

YN350090 (rel)-AR234960 1408311-94-3

(rel)-AR234960 is an active relative configuration of AR234960. AR234960, a non-peptideMAS(a G protein-coupled receptor) agonist, increases both mRNA and protein levels of CTGF via ERK1/2 signaling in HEK293-MAS ...

YN350166 XMD17-109 1435488-37-1

ERK5-IN-1 is a potent, and selective ERK5 inhibitor with IC50 of 162 nM.

YN350173 Ravoxertinib 1453848-26-4

Ravoxertinib (GDC-0994) is an orally bioavailableERKkinase inhibitor with an IC50 of 6.1nM and 3.1nM forERK1 and ERK2, respectively.

YN350084 CC-90003 1621999-82-3

CC-90003 is an irreversible inhibitor of ERK1/2 with IC50s in the 10-20 nM range and shows good kinase selectivity in a 258-kinase biochemical assay.

YN350078 KO-947 1695533-89-1

KO-947 is a potent and selective inhibitor ofERK1/2kinases with potential utility in MAPK pathway dysregulated tumors.

YN350122 ERK5-IN-2 1888305-96-1

ERK5-IN-2 is an orally active, sub-micromolar, selective ERK5 inhibitor with IC50 of 0.82 μM and 3 μM for ERK5 and ERK5 MEF2D, respectively.

YN350012 LY3214996 1951483-29-6

LY3214996 is a selective and novel ERK1/2 inhibitor with IC50 of 5 nM for both enzymes in biochemical assays. It potently inhibits cellular phospho-RSK1 in BRAF and RAS mutant cancer cell lines.

YN350171 Ulixertinib hydrochloride 1956366-10-1

Ulixertinib hydrochloride (BVD-523 hydrochloride) is a potent, orally active, highly selective, ATP-competitive and reversible covalent inhibitor ofERK1/2kinases, with an IC50 of <0.3nM against ERK2. Ulixertinib hydrochlo...

YN350014 AX-15836 2035509-96-5

AX-15836 is a potent and selectiveERK5inhibitor with an IC50 of 8nM.

YN350174 Ravoxertinib hydrochloride 2070009-58-2

Ravoxertinib hydrochloride (GDC-0994 hydrochloride) is an orally bioavailable inhibitor selective forERKkinase activity with IC50 of 6.1nM and 3.1nM forERK1 and ERK2, respectively.

YN350080 ERK1/2 inhibitor 1 2095719-90-5

ERK1/2 inhibitor 1 is a potent, orally bioavailableERK1/2inhibitor, showing 60% inhibition at 1nM and an IC50 of 3.0nM against ERK1 and ERK2, respectively.

YN350116 ERK1/2 inhibitor 2 2095719-92-7

ERK1/2 inhibitor 2 (Example 1) is a potent dualERK1/2inhibitor. ERK1/2 inhibitor 2 has anti-cancer activity.

YN350071 AZD-0364 2097416-76-5

AZD-0364 is a potent and selectiveERK2inhibitor extracted from patent WO2017080979A1, compound example 18, has an IC50 of 0.6nM.

YN350060 JWG-071 2250323-50-1

JWG-071 is the first reported kinase-selective chemical probe forERK5. JWG-071 improves ERK5 activity and BRD4 selectivity. JWG-071 will be a much-needed chemical probe for deconvoluting ERK5 and BRD4 pharmacolog...