YN350255 Hirsutenone 41137-87-5

Hirsutenone is an active botanical diarylheptanoid present in Alnus species and exhibits many biological activities, including anti-inflammatory, anti-tumor promoting and anti-atopic dermatitis effects. Hirsutenone attenuates adipoge...

YN350119 Muramyl dipeptide 53678-77-6

Muramyl dipeptide (MDP) is a syntheticimmunoreactive peptide, consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln. Muramyl dipeptide is an inducer ofbone formationthrough induction ofRunx2. ...

YN350247 Deltonin 55659-75-1

Deltonin, a steroidal saponin, isolated fromDioscorea zingiberensis Wright, with antitumor activity; Deltonin inhibitsERK1/2 and AKTactivation.

YN350250 Methylnissolin 73340-41-7

Methylnissolin (Astrapterocarpan), isolated fromAstragalus membranaceus, inhibitsplatelet-derived growth factor (PDGF)-BB-induced cell proliferation with an IC50 of 10μM. Methylnissolin inhibits PDGF-BB-induced phosphory...

YN350048 Hypothemycin 76958-67-3

Hypothemycin, a fungal polyketide, is a multikinase inhibitor with Kis of 10/70nM, 17/38nM, 90nM, 900nM/1.5μM, and 8.4/2.4μM forVEGFR2/VEGFR1,MEK1/MEK2,FLT-3,PDGFRβ/PDGFRα, and ERK1/ERK2, re...

YN350246 Chicanine 78919-28-5

Chicanine is a lignan compound ofSchis and ra chinesis, inhibits LPS-induced phosphorylation ofp38 MAPK,ERK 1/2 and IκB-α, with anti-inflammatory activity.

YN350228 Astragaloside IV 84687-43-4

Astragaloside IV is a bioactive saponin first isolated from the dried plant roots of the genus Astragalus, which is used in traditional Chinese medicine. It has various effect on the cardiovascular, immune, digestive, and nervous syst...

YN350200 Tauroursodeoxycholate dihydra... 117609-50-4

Tauroursodeoxycholate dihydrate (TUDCA dihydrate; UR 906 dihydrate; Taurolite dihydrate) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such asca...

YN350055 AG126 118409-62-4

AG126 is a tyrosine kinase inhibitor which selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42) at 25-50 μM.

YN350238 Loureirin B 119425-90-0

Loureirin B (LB, LrB), a flavonoid extracted from Dracaena cochinchinensis, is an inhibitor of PAI-1 with IC50 of 26.10 μM. Loureirin B downregulates p-ERK and p-JNK in TGF-β1-stimulated fibroblasts. Loureirin B ...

YN350258 Tenuifoliside A 139726-35-5

Tenuifoliside A is isolated fromPolygala tenuifolia, has anti-apoptotic and antidepressant-like effects. Tenuifoliside A exhibits its neneurotrophic effects and promotes cell proliferation through theERK/CREB/BDNFsignal ...

YN350190 DEL-22379 181223-80-3

DEL-22379 is a water-soluble ERK dimerization inhibitor with IC50 of ?0.5 μM.

YN350125 Bohemine 189232-42-6

Bohemine is a CDK inhibitor with IC50s of 4.6, 83, and 2.7 μM for Cdk2/cyclin E, Cdk2/cyclin A, and Cdk9/cyclin T1, respectively.

YN350178 Omtriptolide 195883-06-8

Omtriptolide (PG490-88) is a water soluble derivative prodrug of triptolide purified from the Chinese herb.

YN350097 BIX02188 334949-59-6

BIX02188 is a potentMEK5-selective inhibitor with an IC50 of 4.3nM. BIX02188 inhibitsERK5catalytic activity, with an IC50 of 810nM.

YN350038 LM22B-10 342777-54-2

LM22B-10 is an activator ofTrkB/TrkCneurotrophin receptor, and can induceTrkB,TrkC,AKT and ERKactivation in vitro and in vivo.

YN350047 Pluripotin 839707-37-8

Pluripotin (SC1) is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP with Kd values of 98 nM and 212 nM respectively. It maintains embryonic stem cell (ESC) self-renewal.

YN350107 FR 180204 865362-74-9

FR 180204 is an ATP-competitive, selective ERK inhibitor with Ki of 0.31 μM and 0.14 μM for ERK1 And ERK2, respectively. It is 30-fold less potent against the related kinase p38α and failed to inhibit any kinases(MEK...

YN350170 Ulixertinib 869886-67-9

Ulixertinib (BVD-523, VRT752271) is a potent and reversible ERK1/ERK2 inhibitor with IC50 of <0.3 nM for ERK2. Phase 1.

YN350142 VX-11e 896720-20-0

VX-11e is a potent, selective, and orally bioavailable ERK2 inhibitor with Ki of <2 nM, over 200-fold selective over other kinases tested.