Darusentan
Cat. No. :YN320976
CAS No. :171714-84-4
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order@ubiochem.com| Product Name: | Darusentan |
| CAS NO.: | 171714-84-4 |
| Chemical Name: | |
| Synonyms: | |
| Molecular Weight: | 410.42 |
| Molecular Formula: | C₂₂H₂₂N₂O₆ |
| SMILES: | COC1=NC(O[C@H](C(O)=O)C(C2=CC=CC=C2)(C3=CC=CC=C3)OC)=NC(OC)=C1 |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | Darusentan (Lu-135252) is a selectiveendothelin receptor A(ET-A)receptorantagonist, which binds with a Ki of 1.4nM to the ET-A receptor and a Kiof 184nM to ET-B receptor, respectively with a 100-fold selectivity for ETA rather than ETB receptors. Darusentan competes for radiolabeled endothelin binding in rat aortic vascular smooth muscle cells (RAVSMs) membranes with single-site kinetics, exhibiting a Ki of 13nM. |
| IC50&Target: | |
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