NAMI-A
Cat. No. :YN440390
CAS No. :201653-76-1
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order@ubiochem.com| Product Name: | NAMI-A |
| CAS NO.: | 201653-76-1 |
| Chemical Name: | |
| Synonyms: | |
| Molecular Weight: | 458.18 |
| Molecular Formula: | C₅H₁₀Cl₄N₂ORuS . C₃H₄N₂ . H |
| SMILES: | Cl[Ru](Cl)(Cl)(Cl)(C)[N]1=CNC=C1.O=S(C)C.[-].[H+].C2=CNC=N2 |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | NAMI-A is a ruthenium-based drug characterised by the selective activity against tumour metastases, inhibits the adhesion and migration. In vitro: NAMI-A can significantly affect tumor cells with metastatic ability. The half lifetime of NAMI-A elimination from the lungs is longer than for liver, kidney, and primary tumor. NAMI-A bound to collagen is active on tumor cells as shown in vitro by an invasion test, using a modified Boyden chamber and Matrigel, and it inhibits the matrix metallo-proteinases MMP-2 and MMP-9 at micromolar concentrations. The ruthenium drug NAMI-A inhibits the adhesion and migration of colorectal cancer cells. NAMI-A decreases α5β1 integrin expression and FAK auto-phosphorylation on Tyr 397. In vivo: The reference for NAMI-A is 35 mg/kg/day. |
| IC50&Target: | |
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| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: | |
| References: |
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