YN420190 GSK-3 inhibitor 1 603272-51-1

GSK-3 inhibitor 1 is an inhibitor ofGSK-3.

YN420236 LY2090314 603288-22-8

LY2090314 is a potent GSK-3 inhibitor for GSK-3α/β with IC50 of 1.5 nM/0.9 nM may improve the efficacy of platinum-based chemotherapy regimens. LY2090314 is highly selective towards GSK3 as demonstrated by its fold select...

YN420186 AZD1080 612487-72-6

AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor, inhibits human GSK3α and GSK3β with Ki of 6.9 nM and 31 nM, respectively, shows >14-fold selectivity against CDK2, CDK5, CDK1 and Erk2.

YN420052 GSK 3 Inhibitor IX 667463-62-9

BIO is a specific inhibitor of GSK-3 with IC50 of 5 nM for GSK-3α/β in a cell-free assay, shows >16-fold selectivity over CDK5, also a pan-JAK inhibitor.

YN420211 BIO-acetoxime 667463-85-6

BIO-acetoxime is a potent dual GSK3α/β inhibitor with IC50 of 10 nM, >240-fold selectivity over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B.

YN420280 1-Azakenpaullone 676596-65-9

1-Azakenpaullone is a potent and selective GSK-3β inhibitor with IC50 of 18 nM, >100-fold selectivity over CDK1/cyclin B and CDK5/p25.

YN420004 R547 741713-40-6

R547 is a potent ATP-competitive inhibitor of CDK1/2/4 with Ki of 2 nM/3 nM/1 nM. It is less potent to CDK7 and GSK3α/β, while inactive to other kinases. Phase 1.

YN420322 Phospho-Glycogen Synthase P... 851366-97-7

Phospho-Glycogen Synthase Peptide-2 (substrate) is peptide substrate for glycogen synthase kinase-3 (GSK-3) and can be used for affinity purification of protein-serine kinases.

YN420195 Tideglusib 865854-05-3

Tideglusib is an irreversible, non ATP-competitive GSK-3β inhibitor with IC50 of 60 nM in a cell-free assay fails to inhibit kinases with a Cys homologous to Cys-199 located in the active site. Phase 2.

YN420074 BIP-135 941575-71-9

BIP-135 is a potent and selective ATP-competitiveGSK-3inhibitor, with IC50s of 16nM and 21nM for GSK-3α and GSK-3β, respectively. BIP 135 exhibits neuroprotective effect.

YN420093 9-ING-41 1034895-42-5

9-ING-41 is a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with antitumor activity. 9-ING-41 induces apoptosis and cell cycle arrest at prophase by targeting centrosomes and microtubule-bound GSK3β.

YN420118 IM-12 1129669-05-1

IM-12 is a selective GSK-3β inhibitor with IC50 of 53 nM, and also enhances canonical Wnt signalling.

YN420058 A 1070722 1384424-80-9

A 1070722 is a potent and selectiveglycogen synthase kinase 3 (GSK-3)inhibitor, with a Ki of 0.6nM for both GSK-3α and GSK-3β. A 1070722 can penetrate the blood-brain barrier (BBB) and accumulates in brain regions, t...

YN420077 EHT 5372 1425945-60-3

EHT 5372 is a strong inhibitor ofDYRK’sfamily kinases, with IC50s of 0.22, 0.28nM for DYRK1A and DYRK1B, respectively.

YN420151 GSK-3β inhibitor 2 1702428-31-6

GSK-3β inhibitor 2 (Compound 3) is a potent, selective and orally activeGSK-3βinhibitor with an IC50 of 1.1nM. GSK-3β inhibitor 2 can cross the blood-brain barrier. GSK-3β inhibitor 2 has the potential for Alzheimer's...

YN420031 CHIR-99021 trihydrochlorid... 1782235-14-6

CHIR-99021 trihydrochloride (CT99021 trihydrochloride) is a potent and selectiveGSK-3α/βinhibitor with IC50s of 10nM and 6.7nM. CHIR-99021 trihydrochloride shows >500-fold selectivity forGSK-3over CDC2, ERK2 ...

YN420030 CHIR-99021 monohydrochlori... 1797989-42-4

CHIR-99021 HCl (CT99021) is hydrochloride of CHIR-99021, which is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM CHIR-99021 shows greater than 500-fold selectivity for GSK-3 versus its closest homologs Cdc2 and ...

YN420145 GNF4877 2041073-22-5

GNF4877 is a potentDYRK1A and GSK3βinhibitor with IC50s of 6 nM and 16 nM, respectively, which leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export and increased β-cell proliferation (E...

YN420097 BRD0705 2056261-41-5

BRD0705 is a potent, paralog selective and orally activeGSK3αinhibitor with an IC50 of 66nM and aKdof 4.8μM. BRD0705 displays increased selectivity forGSK3α(8-fold) versus GSK3β (IC50 of 515nM). BRD0705 can...

YN420127 BRD3731 2056262-07-6

BRD3731 is a selectiveGSK3βinhibitor, with IC50s of 15nM and 215nM for GSK3β and GSK3α, respectively. BRD3731 can be used for the research of a mood disorder, post-traumatic stress disorder (PTSD), psychiatric ...