CHIR-99021 trihydrochloride
Cat. No. :YN420031
CAS No. :1782235-14-6
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order@ubiochem.com| Product Name: | CHIR-99021 trihydrochloride |
| CAS NO.: | 1782235-14-6 |
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| Molecular Weight: | 574.72 |
| Molecular Formula: | C₂₂H₂₁Cl₅N₈ |
| SMILES: | N#CC1=CC=C(NCCNC2=NC=C(C3=NC=C(C)N3)C(C4=CC=C(Cl)C=C4Cl)=N2)N=C1.[H]Cl.[H]Cl.[H]Cl |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | CHIR-99021 trihydrochloride (CT99021 trihydrochloride) is a potent and selectiveGSK-3α/βinhibitor with IC50s of 10nM and 6.7nM. CHIR-99021 trihydrochloride shows >500-fold selectivity forGSK-3over CDC2, ERK2 and other protein kinases. CHIR-99021 trihydrochloride is also a potentWnt/β-cateninsignaling pathway activator. CHIR-99021 trihydrochloride enhances mouse and human embryonic stem cells self-renewal. CHIR-99021 trihydrochloride inducesautophagy . |
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