PF-3644022
Cat. No. :YN350049
CAS No. :1276121-88-0
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order@ubiochem.com| Product Name: | PF-3644022 |
| CAS NO.: | 1276121-88-0 |
| Chemical Name: | |
| Synonyms: | |
| Molecular Weight: | 374.46 |
| Molecular Formula: | C₂₁H₁₈N₄OS |
| SMILES: | O=C1C2=C(NC[C@@H](C)N1)C3=C(C=CC4=NC(C5=CN=C(C)C=C5)=CC=C34)S2 |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | PF-3644022 is a potent, selective, orally active and ATP-competitiveMAPKAPK2 (MK2)inhibitor with an IC50 of 5.2nM and a Ki of 3nM. PF-3644022 also inhibits MK3 and p38 regulated/activated kinase (PRAK)with IC50s of 53nM and 5.0nM, respectively. PF-3644022 potently inhibits TNFα production and has anti-inflammatory effect. |
| IC50&Target: | |
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