YN290507 Bezafibrate 41859-67-0

Bezafibrate is the first clinically tested dual and pan-PPAR co-agonism.

YN440412 Tolimidone 41964-07-2

MLR-1023 is a Lyn kinase activator and a novel insulin receptor potentiator that elicits a rapid-onset and durable improvement in glucose homeostasis in animal models of type 2 diabetes.

YN373411 2-(2',3',4'-Trihydroxybutyl)q... 42015-38-3

2-(2',3',4'-Trihydroxybutyl)quinoxaline is a food metabolite. 2-(2',3',4'-Trihydroxybutyl)quinoxaline can be formed from homoglucans.

YN330458 Fenofibric acid 42017-89-0

Fenofibric acid is a fibrate that acts as a lipid-lowering agent, decreasing low-density lipoprotein cholesterol and triglycerides.

YN372969 ATP dipotassium 42373-41-1

ATP dipotassium (Adenosine 5'-triphosphate dipotassium) is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP dipotassium is...

YN270569 Beta-Zearalanol 42422-68-4

Beta-Zearalenol is anmycotoxinproduced byFusariumspp, which causesapoptosis and oxidative stress in mammalian reproductive cells. Beta-Zearalenol is the derivative of zearalenone (ZEA) which can conjugate with glucuronic acid.

YN481021 NNMTi 42464-96-0

NNMTi is a potent nicotinamide N-methyltransferase (NNMT) inhibitor (IC50=1.2μM) and selectively binds to the NNMT substrate-binding site residues. NNMTi  promotes myoblast differentiation in vitro and enhances f...

YN371683 bpV(phen) 42494-73-5

bpV(phen) is a potentprotein tyrosine phosphatase (PTP) and PTENinhibitor with IC50s of 38nM, 343nM and 920nM forPTEN,PTP-β and PTP-1B, respectively. bpV(phen) inhibits proliferation of the protozoanparasiteLeis...

YN373112 Pedunculoside 42719-32-4

an inhibitior of human carbonic anhydrase 9

YN320544 Bevantolol hydrochloride 42864-78-8

Bevantolol hydrochloride is a cardioselective, beta adrenoceptor antagonist, devoid of intrinsic β sympathomimetic activity and with weak membrane-stabilizing and local anesthetic properties.

YN484278 Phentolamine Analogue 1 47142-51-8

Phentolamine Analogue 1 is an analogue of phentolamine. Phentolamine is a nonselectivealpha-adrenergicantagonist.

YN372451 ZLN005 49671-76-3

ZLN005 is a potent and tissue-specific PGC-1α transcriptional activator.

YN374279 2,6-Dioxo-1,2,3,6-tetrahydrop... 50887-69-9

2,6-Dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid hydrate is an endogenous metabolite.

YN290411 Pirinixic acid 50892-23-4

WY 14643 (Pirinixic Acid) is a potent peroxisome proliferator and activator of PPARα with EC50 of 1.5 μM.

YN360453 Verapamil EP Impurity C h... 51012-67-0

NSC-609249 hydrochloride is animpurityof Verapamil (HY-14275). Verapamil is acalcium channelblocker and a potent and orally active first-generationP-glycoprotein (P-gp)inhibitor.

YN321747 Licarin A 51020-86-1

Licarin A ((+)-Licarin A), a neolignan isolated from various plants, significantly and dose-dependently reduces TNF-α production (IC50=12.6±0.3μM) in dinitrophenyl-human serum albumin (DNP-HSA)-stimulated RBL-2H3 ce...

YN360931 Licarin B 51020-87-2

Licarin B, a nitric oxide production inhibitor extracted from the component of the seeds ofMyristica fragrans, improves insulin sensitivity viaPPARγ and activation of GLUT4 in the IRS-1/PI3K/AKT pathway .

YN481796 Acipimox 51037-30-0

Acipimox is a niacin derivative used as a hypolipidemic agent.

YN370717 (S)-3,4-Dihydroxybutyric aci... 51267-44-8

(S)-3,4-Dihydroxybutyric acid is a normal human urinary metabolite that is excreted in increased concentration in patients with succinic semialdehyde dehydrogenase (SSADH) deficiency.

YN483347 Deoxynivalenol 51481-10-8

Deoxynivalenol, a mycotoxin of the trichothecenes family, crosses the intestinal mucosa by a paracellular pathway through the tight junctions. The Deoxynivalenol transport is not affected by P-glycoprotein (PgP) or multidrug resistanc...