YN370515 LMPTP INHIBITOR ... 2310135-46-5

LMPTP INHIBITOR 1 (dihydrochloride) is a selective inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP), with an IC50 of 0.8μM LMPTP-A.

YN371641 PDK4-IN-1 hydrochloride 2310262-11-2

PDK4-IN-1 hydrochloride is an anthraquinone derivative and a potent and orally activepyruvate dehydrogenase kinase 4 (PDK4)inhibitor with an IC50 value of 84nM. PDK4-IN-1 hydrochloride potently represses cellular transfo...

YN480387 Ceapin-A7 2323027-38-7

Ceapin-A7 is a selective blocker ofATF6α signalingin response to ER stress, with an IC50 of 0.59μM. Ceapin-A7 can be used to explore both the mechanism of activation of ATF6α and its role in pathological settings.

YN480470 RXFP3/4 agonist 1 2351104-40-8

RXFP3/4 agonist 1 is an agonist of relaxin family peptide 3/4 receptor (RXFP3/4), with EC50s of 82/2nM, respectivley. RXFP3/4 agonist 1 increases food intake in rats.

YN371055 SWE101 2376322-12-0

SWE101 (compound 22 b) is a potentsoluble epoxide hydrolase (sEH)-Pinhibitor with IC50s of 4μM and 2.8μM for human and rat sEH-P, respectively. SWE101 does not inhibit neither hydrolase nor phosphatase activity of the ...

YN320253 Calhex 231 hydrochloride 2387505-78-2

Calhex 231 hydrochloride is aCaSRinhibitor via negative allosteric modulation. Calhex 231 hydrochloride blocks Ca2+-induced accumulation of [3H]inositol phosphate with an IC50 of 0.39μM in HEK293 cells. Calhex 231 hydrochlori...

YN481024 yGsy2p-IN-1 2415003-97-1

yGsy2p-IN-1 is a potent inhibitor foryeast glycogen synthase 2 (yGsy2p). yGsy2p-IN-1 is a competitivehuman glycogen synthase 1 (hGYS1)inhibitor with an IC50 of 2.75 µM and a Ki of 1.31 µM for wild-type hGYS1. yGsy2p-I...

YN310160 Nicotinamide riboside tartrat... 2415657-86-0

Nicotinamide riboside tartrate, an orally active NAD+precursor, increases NAD+levels and activatesSIRT1 and SIRT3. Nicotinamide riboside tartrate is a source of vitamin B3 (niacin) and enhances oxidative metabolism, pro...

YN310161 Nicotinamide riboside malate 2415659-01-5

Nicotinamide riboside malate, an orally active NAD+precursor, increases NAD+levels and activatesSIRT1 and SIRT3. Nicotinamide riboside malate is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protect...

YN410049 CBR-470-2 2416095-00-4

CBR-470-2, a glycine-substituted analog, and can activateNRF2signaling. CBR-470-2 can be used for modulation glycolysis.

YN410050 CBR-470-1 2416095-06-0

CBR-470-1 is an inhibitor of theglycolytic enzyme phosphoglycerate kinase 1 (PGK1). CBR-470-1 is also a non-covalentNrf2activator. CBR-470-1 protects SH-SY5Y neuronal cells against MPP+-induced cytotoxicity through acti...

YN5340025 ALK2-IN-4 succinate 2416307-25-8

ALK2-IN-4 succinate is a potentALK2inhibitor extracted from patent WO2020086963A1, compound Formula I free base.

YN370803 HMG499 2416941-68-7

HMG499 is a potent and selectiveHMG-CoA reductaseinhibitor with an IC50 of 0.41μM. HMG499 can prevent statins-induced accumulation of HMGCR, reduce serum cholesterol levels and decrease atherosclerosis.

YN481690 (R)-BAY-85-8501 2446175-39-7

(R)-BAY-85-8501 is the less active Enantiomer of BAY-85-8501. BAY-85-8501 is a selective and potent inhibitor ofHuman Neutrophil Elastase (HNE), with an IC50 of 65 pM.