Chemical structure
Cat.No.
Product Name
CAS no.
Target
AT-007 is an orally active central nervous system (CNS) penetrantAldose Reductaseinhibitor for treatment of Galactosemia with an IC50 value of 100 pM. AT-007 reduces toxic galactitol levels and prevents disease complications ...
YN480969 Vanin-1-IN-1 2173134-00-2
Vanin-1-IN-1 is an inhibitor of vanin-1 enzyme which is a cell surface associated, giycosyiphosphatidyS inositol (GPi) anchored protein and plays an important role in metabolism and inflammation.
YN1720003 GLP-1 receptor agonist 1 2212020-52-3
GLP-1 receptor agonist 1 is a GLP-1 receptor agonist extracted from patent WO2018056453A1, Compound 67.
KY19382 is a potent and orally active dual inhibitor ofCXXC5-DVL and GSK3β, with IC50s of 19 and 10nM, respectively. KY19382 activates Wnt/β-catenin signaling through inhibitory effects on both CXXC5-DVL inter...
YN360272 PF-06869206 2227425-05-8
PF-06869206 is an orally bioavailable selective inhibitor of the sodium-phosphate cotransporterNaPi2a(SLC34A1) with an IC50 of 380nM.
YN360336 BI 01383298 2227549-00-8
BI 01383298 is a potent inhibitor of thesodium-citrate co-transporter (SLC13A5)that is highly expressed in the liver.
YN1720008 PF-06882961 2230198-02-2
PF-06882961, a non-peptide agonist, activates the canonical G protein signaling activity only in the Glucagon-like peptide-1 (GLP-1) receptor with Trp33ECD.
YN410033 Keap1-Nrf2-IN-1 2232112-72-8
Keap1-Nrf2-IN-1 (compound35) is aKelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2 (Keap1-Nrf2) protein-protein interactioninhibitor, and with an IC50 of 43nM for Keap1 protein. Keap1-Nrf2-IN...
YN371049 SBI-797812 2237268-08-3
SBI-797812 is a NAMPT activator which is structurally similar to active-site directed NAMPT inhibitors and blocks binding of these inhibitors to NAMPT. SBI-797812 turns NAMPT into a "super catalyst" t...
YN320599 BTRX-335140 2244614-14-8
BTRX-335140 (CYM-53093) is a potent and selective, orally activeκ opioid receptor (KOR)antagonist, has antagonist activity for κOR, μOR and δOR with IC50 values of 0.8nM, 110nM, and 6500nM, respectively. BTR...
YN480608 ELX-02 disulfate 2244622-33-9
ELX-02 disulfate (NB-124 disulfate) is an investigational, advanced synthetic eukaryotic ribosome selective glycoside (ERSG). ELX-02 disulfate is being developed as a therapy for genetic diseases caused by nonsense mutations.
YN480570 TUG-1375 2247372-59-2
TUG-1375 is an agonist of free fatty acid receptor 2 (FFA2/GPR43), with a pKi of 6.69. TUG-1375 is inactive on FFA3, FFA4, PPARα, PPARγ, PPARδ, LXRα or LXRβ.
YN5340024 ALK2-IN-4 2248154-85-8
ALK2-IN-4 is a potentALK2inhibitor extracted from patent WO2020086963A1, compound Formula I free base.
YN371556 PF429242 dihydrochloride 2248666-66-0
PF429242 dihydrochloride is a reversible and competitiveSREBPsite 1 protease (S1P) inhibitor with an IC50 of 175nM.
YN330126 nor-NOHA monoacetate 2250019-93-1
nor-NOHA (Nω-Hydroxy-nor-L-arginine) monoacetate is a potent and selectivearginaseinhibitor. nor-NOHA monoacetate inhibits rat liver arginase with a Kiof 0.5 µM.
YN480987 Hypoglycemic agent 1 2253733-57-0
Hypoglycemic agent 1 acts as a therapeutic and /or prophylactic agent for diabetes. Hypoglycemic agent 1 has an action for lowering blood sugar.
YN480606 DJ-V-159 2253744-53-3
DJ-V-159 is an agonist for G protein-coupled receptor family C group 6 member A(GPRC6A).
OSMI-4 is an inhibitor of O-linked N-acetylglucosamine transferase (O-GlcNAc transferase, OGT) with EC50 of 3 μM in cells.
RU.521 is an active, potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS) that inhibits the cGAS-mediated signaling with IC50 of 700 nM. RU.521 binds to the cGAS/dsDNA complex with Kd of 36.2 nM...
YN270120 UAMC-3203 hydrochloride 2271358-65-5
UAMC-3203 hydrochloride is a potent and selectiveFerroptosisinhibitor with an IC50 of 12nM.
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