E7449
Cat. No. :YN290194
CAS No. :1140964-99-3
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order@ubiochem.com| Product Name: | E7449 |
| CAS NO.: | 1140964-99-3 |
| Chemical Name: | |
| Synonyms: | |
| Molecular Weight: | 317.34 |
| Molecular Formula: | C₁₈H₁₅N₅O |
| SMILES: | O=C1NNC2=C3C1=CC=CC3=NC(CN4CC5=C(C=CC=C5)C4)=N2 |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | E7449 is an orally bioavailable, brain penetrable, small molecule dual inhibitor of PARP1/2 and also inhibits PARP5a/5b, otherwise known as tankyrase1 and 2 (TNKS1/2), important regulators of canonical Wnt/β-catenin signaling. It has IC50 values of 1.0 and 1.2 nM for PARP1 and 2, respectively. |
| IC50&Target: | |
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