SNIPER(BRD)-1
Cat. No. :YN430061
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order@ubiochem.com| Product Name: | SNIPER(BRD)-1 |
| CAS NO.: | 2095244-54-3 |
| Chemical Name: | |
| Synonyms: | |
| Molecular Weight: | 1056.73 |
| Molecular Formula: | C₅₃H₆₆ClN₉O₈S₂ |
| SMILES: | O=C(C[C@H]1C2=NN=C(C)N2C(SC(C)=C3C)=C3C(C4=CC=C(Cl)C=C4)=N1)NCCOCCOCCOCCOC5=CC(C(C6=CSC([C@H]7N(C([C@@H](NC([C@H](C)NC)=O)C8CCCCC8)=O)CCC7)=N6)=O)=CC=C5 |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | SNIPER(BRD)-1, consists of an IAP antagonist LCL-161 derivative and a BET inhibitor, (+)-JQ-1, connected by a linker. SNIPER(BRD)-1 induces the degradation ofBRD4via the ubiquitin-proteasome pathway. SNIPER(BRD)-1 also degrades cIAP1 , cIAP2 and XIAP with IC50s of 6.8nM, 17nM, and 49nM, respectively. |
| IC50&Target: | |
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| Clinical Trial: | |
| Solvent & Solubility: | |
| References: |
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