K-Ras ligand-Linker Conjugate 5
Cat. No. :YN430182
CAS No. :2378261-85-7
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order@ubiochem.com| Product Name: | K-Ras ligand-Linker Conjugate 5 |
| CAS NO.: | 2378261-85-7 |
| Chemical Name: | |
| Synonyms: | |
| Molecular Weight: | 789.96 |
| Molecular Formula: | C₄₂H₅₉N₇O₈ |
| SMILES: | O=C(N1[C@@H](CC#N)CN(C2=C3C(CN(C4=C5C=CC=CC5=CC=C4)CC3)=NC(OC[C@H]6N(C)C[C@H](OCCOCCOCCOCCO)C6)=N2)CC1)OC(C)(C)C |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Transportation: | Room temperature in continental US; may vary elsewhere. |
| Description: | K-Ras lig and -Linker Conjugate 5 incorporates a lig and for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras lig and -Linker Conjugate 5 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells. |
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