K-Ras ligand-Linker Conjugate 4
Cat. No. :YN430181
CAS No. :2378261-83-5
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Product Name: | K-Ras ligand-Linker Conjugate 4 |
CAS NO.: | 2378261-83-5 |
Chemical Name: | |
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Molecular Weight: | 697.82 |
Molecular Formula: | C₃₅H₅₁N₇O₈ |
SMILES: | O=C(N1[C@@H](CC#N)CN(C2=C3C(CNCC3)=NC(OC[C@H]4N(C)C[C@H](OCCOCCOCCOCCO)C4)=N2)CC1)OCC5=CC=CC=C5 |
Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
Transportation: | Room temperature in continental US; may vary elsewhere. |
Description: | K-Ras lig and -Linker Conjugate 4 incorporates a lig and for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras lig and -Linker Conjugate 4 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells. |
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