Chemical structure
Cat.No.
Product Name
CAS no.
Target
YN340008 Tyrphostin AG 528 133550-49-9
Tyrphostin AG-528 is a potent inhibitor of epidermal growth factor receptors (EGFR) and ErbB2/HER2 with IC50 of 4.9 μM and 2.1 μM, respectively. Tyrphostin AG-528 exhibits anticancer activity.
RG-13022 inhibits the autophosphorylation reaction of the EGF receptor in immunoprecipitates with IC50 of 4 µM.
RG14620, an EGFR inhibitor of the tyrphostin family, directly inhibits the transport function of ABCG2 .
YN340078 Tyrphostin AG 112 144978-82-5
Tyrphostin AG 112 is anEGFR phosphorylationinhibitor.
CGP52411 (DAPH) is a high selective, potent, orally active and ATP-competitiveEGFRinhibitor with an IC50 of 0.3μM. CGP52411 blocks the toxic influx of Ca2+ions into neuronal cells, and dramatic inhibits and rever...
YN340229 Tyrphostin AG 879 148741-30-4
Tyrphostin AG 879 potently inhibits HER2/ErbB2 with IC50 of 1 μM, 100- and 500-fold higher selective to ErbB2 than PDGFR and EGFR.
AG-825 (Tyrphostin AG-825) is a selective and ATP-competitiveErbB2inhibitor which suppresses tyrosine phosphorylation, with an IC50 of 0.35μM. AG-825 displays anti-cancer activity . AG825 significantly accelerates apop...
AG-1478 (Tyrphostin AG-1478) is a selective EGFR inhibitor with IC50 of 3 nM in cell-free assays, almost no activity on HER2-Neu, PDGFR, Trk, Bcr-Abl and InsR.
PD153035 is a specific and potent inhibitor of the epidermal growth factor (EGF) receptor tyrosine kinase (Ki = 5.2 pM).
YN340184 WHI-P180 hydrochloride 153437-55-9
WHI-P180 (Janex 3) is a multi-kinase inhibitor; inhibitsRET,KDR and EGFRwith IC50s of 5nM, 66nM and 4μM, respectively.
YN340136 AG-1478 hydrochloride 170449-18-0
AG-1478 hydrochloride (Tyrphostin AG-1478 hydrochloride) is a selectiveEGFRtyrosine kinase inhibitor with IC50 of 3nM. AG-1478 hydrochloride has antiviral effects againstHCV and encephalomyocarditis virus (EMCV).
PD158780 is a potentEGFRfamily inhibitor with IC50s of 8 pM, 49, 52, 52nM for EGFR, ErbB2, ErbB3, and ErbB4, respectively.
YN340289 pp60 (v-SRC) Autophosphory... 176042-83-4
pp60 (v-SRC) Autophosphorylation Site, Phosphorylated is the phosphorylated peptide of an EGFR substrate. pp60 (v-SRC) Autophosphorylation Site, Phosphorylated can be used for the screening of EGFR Kinase inhibitors via...
YN340077 PD-089828 179343-17-0
PD-089828 is an ATP competitive inhibitor ofFGFR-1,PDGFR-β and EGFR(IC50s=0.15, 1.76, and 5.47 µM, respectively) and a noncompetitive inhibitor ofc-Srctyrosine kinase (IC50=0.18 µM). PD-089828 also inhibits...
YN340291 Trastuzumab 180288-69-1
Trastuzumab is a humanized monoclonal antibody for patients with invasive breast cancers that overexpress HER2. Trastuzumab has the potential for HER2 Positive Metastatic Breast Cancer and HER2 Positive Gastric Cancer re...
YN340091 Erlotinib Hydrochloride 183319-69-9
Erlotinib HCl (OSI-744) is an EGFR inhibitor with IC50 of 2 nM in cell-free assays, >1000-fold more sensitive for EGFR than human c-Src or v-Abl.
YN340243 Erlotinib 183321-74-6
Erlotinib is an EGFR inhibitor with IC50 of 2 nM, >1000-fold more sensitive for EGFR than human c-Src or v-Abl.
YN340095 PD153035 Hydrochloride 183322-45-4
PD153035 Hydrochloride (SU-5271 Hydrochloride) is a potentEGFRinhibitor withKi and IC50 of 6 and 25 pM, respectively.
YN340240 Gefitinib 184475-35-2
Gefitinib (ZD-1839) is an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 in the NR6wtEGFR and NR6W cells with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respectively.
YN340241 Gefitinib hydrochloride 184475-55-6
Gefitinib is an EGFR inhibitor with IC50s of 15.5 nM and 823.3 nM for WT EGFR and EGFR (858R/T790M), respectively.
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