YN340126 EMI56 2414374-41-5

EMI56, the derivative of EMI1, displays greater potency toward mutantEGFRthan EMI1. EMI56 inhibitsEGFRtriple mutants.

YN340146 BDTX-189 2414572-47-5

BDTX-189 is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations with Kd of 0.2 nM, 0.76 nM, 13 nM and 1.2 nM for EGFR, HER2, BLK and RIPK2, reapectively....

YN340122 EGFR-IN-11 2463200-44-2

EGFR-IN-11 is a fourth-generationEGFR-tyrosine kinase inhibitor (EGFR-TKI) with an IC50 of 18nM for triple mutantEGFRL858R/T790M/C797S. EGFR-IN-11 significantly suppresses the EGFR phosphorylation, in...

YN340109 EGFR-IN-8

EGFR-IN-8 is a dualEGFR and c-Metinhibitor, compound 48. EGFR-IN-8 can be a promising c and idate for further development to target EGFR TKI-resistant NSCLC.