YN340045 AV-412

AV-412 (MP412) is anEGFRinhibitor with IC50s of 0.75, 0.5, 0.79, 2.3, 19nM for EGFR, EGFRL858R, EGFRT790M, EGFRL858R/T790M and ErbB2, respectively.

YN340120 Gandotinib 1229236-86-5

Gandotinib (LY2784544) is a potent JAK2 inhibitor with IC50 of 3 nM, effective in JAK2V617F, 8- and 20-fold selective versus JAK1 and JAK3. Phase 2.

YN340247 Mutated EGFR-IN-1 1421372-66-8

Mutated EGFR-IN-1 (Osimertinib analog) is a useful intermediate for the inhibitors design for mutatedEGFR, such as L858R EGFR, Exonl9 deletion activating mutant and T790M resistance mutant. More information can be fo...

YN340155 Mutant EGFR inhibitor 1421373-62-7

Mutant EGFR inhibitor is a potent and selective mutantEGFRinhibitor extracted from patent WO 2013014448 A1; inhibits EGFRL858R, EGFRExon 19 deletion and EGFRT790M.

YN340045 AV-412 451493-31-5

AV-412 (MP412) is anEGFRinhibitor with IC50s of 0.75, 0.5, 0.79, 2.3, 19nM for EGFR, EGFRL858R, EGFRT790M, EGFRL858R/T790M and ErbB2, respectively.

YN330684 Nitroflurbiprofen 158836-71-6

Nitroflurbiprofen is acyclooxygenase(COX) inhibitor with nitric oxide (NO)-donating properties, modulates the increased intrahepatic vascular tone in portal hypertensive cirrhotic rats.

YN350183 Longdaysin 1353867-91-0

Longdaysin is a Casein Kinase inhibitor with IC50 values of 8.8 μM, 5.6 μM, 52 μM and 29 μM for CKIδ, CKIα, ERK2 and CDK7.

YN330480 Ampyrone 83-07-8

4-Aminoantipyrine(Ampyrone) is a metabolite of aminopyrine with analgesic, anti-inflammatory, and antipyretic properties. It is used as a reagent for biochemical reactions producing peroxides or phenols.

YN320094 Spiramide 510-74-7

Spiramide (AMI-193) is a potent and selective antagonist of5-HT2 and dopamine D2 receptor, with Kis of 2nM and 3nM, respectively. Spiramide has >2000-fold selectivity for 5-HT2versus5-HT1C(Ki=4300nM) receptors. Spiramid...

YN320055 Flopropione 2295-58-1

Flopropione is a spasmolytic or antispasmodic agent, and acts as a 5-HT1A receptor antagonist.

YN321629 Trimipramine maleate 521-78-8

Trimipramine maleate is a 5-HT receptor antagonist, with pKis of 6.39, 8.10, 4.66 for 5-HT1C, 5-HT2 and  5-HT1A, respectively.

YN321455 Mirtazapine 85650-52-8

Mirtazapine is an adrenergic and seroton receptor antagonist, used to treat depression.

YN321463 Cyproheptadine hydrochloride 969-33-5

Cyproheptadine HCl is a hydrochloride salt form of cyproheptadine which is a histamine receptor antagonist.

YN320935 Volinanserin 139290-65-6

Volinanserin is a potent and selective antagonist of 5-HT2receptor, with a Ki of 0.36nM, and shows 300-fold selectivity for 5-HT2 receptor over 5-HT1c, alpha-1 and DA D2receptors. Volinanserin has antipsychotic activity.

YN320289 Ketanserin 74050-98-9

Ketanserin is a specific 5-HT2A serotonin receptor antagonist with Ki of 2.5 nM for rat and human 5-HT2A, used as an antihypertensive drug.