YN340142 CK2/ERK8-IN-1

CK2/ERK8-IN-1 is a dualcasein kinase 2 (CK2)(Kiof 0.25 µM) and ERK8(MAPK15, ERK7) inhibitor with IC50s of 0.50μM. CK2/ERK8-IN-1 also binds toPIM1,HIPK2(homeodomain-interacting protein kinase 2), and...

YN340044 HKI-357 848133-17-5

HKI-357 is an irreversible dual inhibitor ofEGFR and ERBB2with IC50s of 34nM and 33nM, respectively. HKI-357 suppresses EGFR autophosphorylation (at Y1068), and AKT and MAPK phosphorylation.

YN340046 AV-412 free base 451492-95-8

AV-412 free base (MP-412 free base) is an EGFRinhibitor with IC50s of 0.75, 0.5, 0.79, 2.3, 19nM for EGFR, EGFRL858R, EGFRT790M, EGFRL858R/T790M and ErbB2, respectively.

YN340008 Tyrphostin AG 528 133550-49-9

Tyrphostin AG-528 is a potent inhibitor of epidermal growth factor receptors (EGFR) and ErbB2/HER2 with IC50 of 4.9 μM and 2.1 μM, respectively. Tyrphostin AG-528 exhibits anticancer activity.

YN340211 PD158780 171179-06-9

PD158780 is a potentEGFRfamily inhibitor with IC50s of 8 pM, 49, 52, 52nM for EGFR, ErbB2, ErbB3, and ErbB4, respectively.

YN340004 AEE788 497839-62-0

AEE788 (NVP-AEE788) is a potent inhibitor of EGFR and HER2/ErbB2 with IC50 of 2 nM and 6 nM, less potent to VEGFR2/KDR, c-Abl, c-Src, and Flt-1, does not inhibit Ins-R, IGF-1R, PKCα and CDK1. P...

YN340039 Falnidamol 196612-93-8

Falnidamol (BIBX 1382) is an orally active, selectiveEGFR tyrosine kinaseinhibitor with an IC50 of 3nM. Falnidamol displays > 1000-fold lower potency against ErbB2 (IC50=3.4μM) and a range of other related tyrosine kina...

YN340047 Canertinib 267243-28-7

Canertinib (CI-1033) is a pan-ErbB inhibitor for EGFR and ErbB2 with IC50 of 1.5 nM and 9.0 nM, no activity to PDGFR, FGFR, InsR, PKC, or CDK1/2/4. Phase 3.

YN340048 Canertinib dihydrochloride 289499-45-2

Canertinib (CI-1033, PD-183805, compound 18) dihydrochloride is a potent and irreversible inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase. Canertinib dihydrochloride inhibits cellular EGFR an...

YN340142 CK2/ERK8-IN-1 1085822-09-8

CK2/ERK8-IN-1 is a dualcasein kinase 2 (CK2)(Kiof 0.25 µM) and ERK8(MAPK15, ERK7) inhibitor with IC50s of 0.50μM. CK2/ERK8-IN-1 also binds toPIM1,HIPK2(homeodomain-interacting protein kinase 2), and...

YN371783 Tamoxifen Citrate 54965-24-1

Tamoxifen Citrate is an antagonist of the estrogen receptor by competitive inhibition of estrogen binding.

YN340260 Artesunate 88495-63-0

Artesunate is a part of the artemisinin group of agents with an IC50 of < 5 μM for small cell lung carcinoma cell line H69. It is a potential inhibitor of STAT-3 and exhibits selective cytotoxicity of cancer cells over normal cel...

YN310285 Inauhzin 309271-94-1

Inauhzin is a cell-permeable SIRT1 inhibitor with an IC50 of 0.7-2 μM and reactivates p53 by inhibiting SIRT1 deacetylation activity.

YN372212 Kaempferol 520-18-3

Kaempferol, a natural flavonol, functions as an ERRα and ERRγ inverse agonist. It inhibits topoisomerase I catalyzed DNA religation and may also inhibit the activity of fatty acid synthase.

YN350097 BIX02188 334949-59-6

BIX02188 is a potentMEK5-selective inhibitor with an IC50 of 4.3nM. BIX02188 inhibitsERK5catalytic activity, with an IC50 of 810nM.