YN340016 TX1-85-1

TX1-85-1 is an irreversible Her3 (ErbB3)inhibitor with an IC50 of 23nM. TX1-85-1 is also the first selective Her3 lig and , which forms a covalent bond with Cys721 located in the ATP-binding site of Her3. TX1-85-1 induces ...

YN340120 Gandotinib 1229236-86-5

Gandotinib (LY2784544) is a potent JAK2 inhibitor with IC50 of 3 nM, effective in JAK2V617F, 8- and 20-fold selective versus JAK1 and JAK3. Phase 2.

YN340077 PD-089828 179343-17-0

PD-089828 is an ATP competitive inhibitor ofFGFR-1,PDGFR-β and EGFR(IC50s=0.15, 1.76, and 5.47 µM, respectively) and a noncompetitive inhibitor ofc-Srctyrosine kinase (IC50=0.18 µM). PD-089828 also inhibits...

YN340211 PD158780 171179-06-9

PD158780 is a potentEGFRfamily inhibitor with IC50s of 8 pM, 49, 52, 52nM for EGFR, ErbB2, ErbB3, and ErbB4, respectively.

YN340016 TX1-85-1 1603845-32-4

TX1-85-1 is an irreversible Her3 (ErbB3)inhibitor with an IC50 of 23nM. TX1-85-1 is also the first selective Her3 lig and , which forms a covalent bond with Cys721 located in the ATP-binding site of Her3. TX1-85-1 induces ...

YN310017 AGK2 304896-28-4

AGK2 is a potent, and selective SIRT2 inhibitor with IC50 of 3.5 μM that minimally affects either SIRT1 or SIRT3 at 10-fold higher levels.

YN360491 GTS-21 dihydrochloride 156223-05-1

GTS-21 dihydrochloride is a selective α7 nicotinic acetylcholine receptor agonist, has recently been established as a promising treatment for inflammation.

YN310266 Selisistat 49843-98-3

Selisistat (EX 527) is a potent and selective SIRT1 inhibitor with IC50 of 38 nM in a cell-free assay, exhibits >200-fold selectivity against SIRT2 and SIRT3. Phase 2.

YN310339 Suramin sodium salt 129-46-4

Suramin sodium salt (Suramin hexasodium salt) is a reversible and competitiveprotein-tyrosine phosphatases (PTPases)inhibitor. Suramin sodium salt is a potent inhibitor ofsirtuins: SirT1 (IC50=297nM), SirT2 (IC50=1.15μM),...