TX1-85-1
Cat. No. :YN340016
CAS No. :1603845-32-4
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5mg
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Product Name: | TX1-85-1 |
CAS NO.: | 1603845-32-4 |
Chemical Name: | |
Synonyms: | |
Molecular Weight: | 580.68 |
Molecular Formula: | C₃₂H₃₆N₈O₃ |
SMILES: | CC(N1CCN(C2CCC(N3N=C(C4=CC(NC(C=C)=O)=C(OC5=CC=CC=C5)C=C4)C6=C3N=CN=C6N)CC2)CC1)=O |
Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
Transportation: | Room temperature in continental US; may vary elsewhere. |
Description: | TX1-85-1 is an irreversible Her3 (ErbB3)inhibitor with an IC50 of 23nM. TX1-85-1 is also the first selective Her3 lig and , which forms a covalent bond with Cys721 located in the ATP-binding site of Her3. TX1-85-1 induces partial degradation of Her3 protein and attenuates Her3-dependent signaling. |
IC50&Target: | |
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Clinical Trial: | |
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References: |
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